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POTENTIAL TC-99M RADIOPHARMACEUTICALS FOR RENAL IMAGING - TRIS(N-SUBSTITUTED-3-HYDROXY-2-METHYL-4-PYRIDINONATO)TECHNETIUM(IV) CATIONS

TitlePOTENTIAL TC-99M RADIOPHARMACEUTICALS FOR RENAL IMAGING - TRIS(N-SUBSTITUTED-3-HYDROXY-2-METHYL-4-PYRIDINONATO)TECHNETIUM(IV) CATIONS
Publication TypeJournal Article
Year of Publication1993
AuthorsEdwards, DS, Liu, SN, Lyster, DM, Poirier, MJ, Vo, C, Webb, GA, Zhang, ZH, Orvig, C
JournalNuclear Medicine and Biology
Volume20
Pagination857-863
Date PublishedOct
Type of ArticleArticle
ISBN Number0883-2897
Keywords3-HYDROXY-4-PYRIDINONES, aluminum, CHEMISTRY, COMPLEXES, gallium, INVIVO
Abstract

A series of monocationic complexes of N-substituted-3-hydroxy-2-methyl-4-pyridinones labeled with technetium(IV)-99m have been evaluated in vivo as potential radiopharmaceuticals. The pyridinones have different substituents at the ring nitrogen atom: ethyl, i-propyl, i-butyl, benzyl, phenyl, p-methoxyphenyl, 3-butoxypropyl and cyclohexyl. Biodistribution studies of the Tc-99m complexes have been carried out in rabbits and mice. High kidney uptake and retention of the radionuclide has been shown in rabbits and mice with the cationic complexes of 3-hydroxy-1-(p-methoxyphenyl)-2-methyl-4-pyridinone and 1-(cyclohexyl)-3-hydroxy-2-methyl-4-pyridinone. These (TcL3+)-Tc-99m compounds appear to be morphologic renal agents.

URL<Go to ISI>://A1993LY63600007