News & Events

Process Research & Development at Abbvie

Friday, February 28, 2020 - 11:00 to 12:00
Moiz Diwan
Event Category: 
Seminar - Seminar
Jason Hein
Chemistry D213

There will be two 30 minute seminars being presented during this time.

Seminar 1: Highlights from the Center of Catalysis at AbbVie

The Center of Catalysis (CoC) at AbbVie focuses on developing organometallic, high-pressure, and bio-catalytic transformations of interest to process chemistry. Various experimental techniques such as high throughput experimentation, reactions under inert atmosphere, reactions under elevated pressure, photoredox, etc. are routinely used to solve challenging catalytic transformations. Three recent chemistry highlights from the group will be discussed. First, an evolving story about biaryl phosphorinanes as novel ligands for cross-coupling reactions. Second, on-going efforts on sustainable, non-precious metal catalysis and third, Ir-catalyzed reactions of sulfoxonium ylides to form azoles. The focus of the presentation will be to demonstrate development of catalytic methods driven by the project needs.      

Seminar 2: Positioning for a Sustainable Future – Continuous Processing, Automation and Predictive Modeling for Efficient Biopharmaceutical Process Development and Manufacturing

The focus on development of new modalities for advanced therapies and challenges with complex drug candidates has driven adoption of novel concepts and technologies in pharmaceutical development and manufacturing. Industry is focusing more on flexible design concepts involving smaller footprints, shorter cycle times, high degree of automation, digitalization, and improved process control. Enabling technologies such as continuous processing, high throughput experimentation and predictive modeling through first principles, as well as machine learning can expedite process development, scale-up and technology transfer while ensuring enhanced process efficiency and delivering quality products. This presentation will share AbbVie’s experiences in integrating these technologies into process development and manufacturing facilities and discuss the challenges and opportunities associated with our approaches.