Abstract:
Amines are a family of chemical compounds of great importance due to their applicability in very diverse fields such as the purification of industrial gases, synthesis of colorants or pharmaceutical products.1 Hydroaminoalkylation is an atom-economic method to produce new amine species via the functionalization of α C-H bond of amines by reacting with alkenes. The development of efficient green chemistry methods for their syntheses is important and of industrial relevance.
Knowledge of the mechanism of this reaction is the clue to controlling and improving the regio- and diastereoselectivity of this process. Early transition metals can be exploited to realize enhanced reactivity and exquisite control.
N,O-chelated early transition metals are state-of-the-art hydroaminoalkylation catalysts known to promote reactivity via the hemilability of the ligands.2 Ferrocene complexes offer modular ways to change their steric and electronic properties as well as high thermal stability.3 This work explores the synthesis, structure and reactivity of new ferrocene substituted N,O-chelated ligands and their early transition metal complexes for realizing advances in enhanced and selective reactivity.
1. S. A. Lawrence, Amines: Synthesis, Properties and Applications, Cambridge University Press, 2004.
2. Chem. Commun., 2018, 54, 12543, ChemCatChem 2019, 11, 5264
3. Chem. Soc. Rev., 2004, 33, 313, Appl Organometal Chem 2016; 30, 62