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Solid-state and solution conformations of eleutherobin obtained from X-ray diffraction analysis and solution NOE data

TitleSolid-state and solution conformations of eleutherobin obtained from X-ray diffraction analysis and solution NOE data
Publication TypeJournal Article
Year of Publication2000
AuthorsCinel, B, Patrick, BO, Roberge, M, Andersen, RJ
JournalTetrahedron Letters
Volume41
Pagination2811-2815
Date PublishedApr
Type of ArticleArticle
ISBN Number0040-4039
KeywordsMICROTUBULE-STABILIZING AGENTS, PACLITAXEL, TAXOL
Abstract

Single crystal X-ray diffraction analysis has revealed the solid-state conformation of the microtubule-stabilizing diterpenoid eleutherobin (1). NOE data obtained for 1 in CDCl3 and DMSO-d(6) are consistent with solution conformations that are virtually identical to the solid state conformation. (C) 2000 Elsevier Science Ltd. All rights reserved.
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