| Title | Spirastrellolide B reveals the absolute configuration of the spirastrellolide macrolide core |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Warabi, K, Williams, DE, Patrick, BO, Roberge, M, Andersen, RJ |
| Journal | Journal of the American Chemical Society |
| Volume | 129 |
| Pagination | 508-509 |
| Date Published | Jan |
| ISBN Number | 0002-7863 |
| Abstract | The new macrolide spirastrellolide B (5) has been isolated from extracts of the marine sponge Spirastrella coccinea collected in Dominica. Chemical transformations of spirastrellolide B have converted it to a bromine-containing crystalline derivative 8 that has a truncated side chain. Singlecrystal X-ray diffraction analysis of the derivative 8 has revealed the absolute configuration of the macrolide core of spirstrellolide B to be 3R,7S,9S,11S,13R,14S,17S,20S,21R,22S,23S,24S,27R,29S,31R,34S,35R,37S,38S . |
| URL | <Go to ISI>://000243503700028 |
