Abstract: Photochemistry is intriguing as a synthetic tool because the absorption of light by an organic molecule results in the formation of exceptionally energetic reactive intermediates that can react in ways that are inaccessible to ground-state molecules. However, this high reactivity is also a challenge for stereoselective synthesis: control over the stereochemistry of photochemical reactions, particularly using enantioselective catalysts, has been a long-standing challenging synthetic problem with few general solutions. We recently developed a method for highly enantioselective [2+2] photocycloaddition reactions using a combination of chiral Lewis acid and transition metal photocatalysis. This dual catalyst approach offers a robust strategy to control the reactivity of a wide range of reactive intermediates that can easily be generated using photoredox catalysis.

Stereocontrol in Photochemical Reactions
Date:
Tuesday, January 16, 2018 - 12:45 to 14:00
Speaker:
Dr. Tehshik P. Yoon
Affiliation:
Department of Chemistry, University of Wisconsin-Madison
Event Category:
LMC - Lectures in Modern Chemistry
Location:
Chemistry B250