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  3. Tao Huan

Tao Huan

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Research and Teaching Interests

Metabolomics, a newly emerging field of ‘omics’ research, is the study of the entire sets of small molecules (termed metabolome, molecular weight < 1500 Da), in a given biological system, such as a cell, organ, whole organism or biofluid. The metabolome is a close counterpart to the genome, the transcriptome and the proteome. Together these four ‘omics’ constitute the building blocks of systems biology. Unlike genes and proteins whose functions are subject to epigenetic regulation and post-translational modifications, respectively, metabolites serve as a direct functional readout of a current cellular state and therefore easier to correlate with phenotype. This fact has made metabolomics particularly useful in the study of environment-gene interactions, the identification of disease biomarkers, and the discovery of drugs.

Mass spectrometry (MS) is an excellent analytical platform to study metabolomics as it is highly sensitive, reproducible and versatile. It measures the masses of metabolites and their fragments to assist in elucidating structure. The goal of our research program is to develop analytical and bioinformatic tools for MS-based metabolomics with a focus on understanding colorectal cancer (CRC) metabolism and seeking its relationship with gut microbiome, environmental exposures, and therapeutics. Our long-term research goal is to drive metabolomics forward and bring it into the toolbox of biological scientists to achieve a more comprehensive understanding of human health and disease.

Our research interests include:

  • Integration of metabolomics with other ‘omics’ (epigenomics, genomics, transcriptomics, and proteomics) data for the systems-level interrogation of biological problems
  • Application of state-of-art metabolomics technologies in various biological challenges, such as mechanistic understanding of cancer metabolism and disease biomarker discovery
  • Synergetic development of analytical and bioinformatic techniques to enhance metabolomic coverage and improve the confidence of metabolite identification

 

Highly motivated students interested in pursuing graduate studies in our research areas are encouraged to contact Dr. Huan (thuan@chem.ubc.ca) during the application process. 

To apply online:

https://www.grad.ubc.ca/prospective-students/application-admission/apply...

Contact

Real name: 
Tao Huan
Email: 
Office Room Number(s): 
D214
Office Phone Number: 
604-822-4891
Lab Room: 
E111
Lab Phone: 
604-827-2196

Curriculum Vitae

Postdoctoral Research Associate, The Scripps Research Institute (La Jolla), USA (2015 - 2018)

Ph.D., Analytical Chemistry, University of Alberta, Canada (2010 - 2015)

B.Sc., Chemistry, Zhejiang University, China (2006 - 2010)

Publications

2020

Chen, D. ; Han, W. ; Huan, T. ; Li, L. ; Li, L. Effects Of Freeze-Thaw Cycles Of Blood Samples On High-Coverage Quantitative Metabolomics. ANALYTICAL CHEMISTRY 2020, 92, 9265-9272.
Guo, J. ; Huan, T. Comparison Of Full-Scan, Data-Dependent, And Data-Independent Acquisition Modes In Liquid Chromatography-Mass Spectrometry Based Untargeted Metabolomics. ANALYTICAL CHEMISTRY 2020, 92, 8072-8080.
Yu, H. ; Xing, S. ; Nierves, L. ; Lange, P. F. ; Huan, T. Fold-Change Compression: An Unexplored But Correctable Quantitative Bias Caused By Nonlinear Electrospray Ionization Responses In Untargeted Metabolomics. ANALYTICAL CHEMISTRY 2020, 92, 7011-7019.
Tang, X. ; Kudo, Y. ; Baker, J. L. ; LaBonte, S. ; Jordan, P. A. ; McKinnie, S. M. K. ; Guo, J. ; Huan, T. ; Moore, B. S. ; Edlund, A. Cariogenic Streptococcus Mutans Produces Tetramic Acid Strain-Specific Antibiotics That Impair Commensal Colonization. ACS INFECTIOUS DISEASES 2020, 6, 563-571.
Chen, D. ; Han, W. ; Huan, T. ; Li, L. ; Li, L. Effects Of Freeze-Thaw Cycles Of Blood Samples On High-Coverage Quantitative Metabolomics. ANALYTICAL CHEMISTRY 2020, 92, 9265-9272.
Yang, J. J. ; Han, Y. ; Mah, C. H. ; Wanjaya, E. ; Peng, B. ; Xu, T. F. ; Liu, M. ; Huan, T. ; Fang, M. L. Streamlined Mrm Method Transfer Between Instruments Assisted With Hrms Matching And Retention-Time Prediction. ANALYTICA CHIMICA ACTA 2020, 1100, 88-96.
Guo, J. ; Huan, T. Comparison Of Full-Scan, Data-Dependent, And Data-Independent Acquisition Modes In Liquid Chromatography-Mass Spectrometry Based Untargeted Metabolomics. ANALYTICAL CHEMISTRY 2020, 92, 8072-8080.
Dong, Y. ; Arif, A. A. ; Guo, J. ; Ha, Z. ; Lee-Sayer, S. S. M. ; Poon, G. F. T. ; Dosanjh, M. ; Roskelley, C. D. ; Huan, T. ; Johnson, P. Cd44 Loss Disrupts Lung Lipid Surfactant Homeostasis And Exacerbates Oxidized Lipid-Induced Lung Inflammation. FRONTIERS IN IMMUNOLOGY 2020, 11, 29.
Yu, H. ; Xing, S. ; Nierves, L. ; Lange, P. F. ; Huan, T. Fold-Change Compression: An Unexplored But Correctable Quantitative Bias Caused By Nonlinear Electrospray Ionization Responses In Untargeted Metabolomics. ANALYTICAL CHEMISTRY 2020, 92, 7011-7019.
Li, L. ; Zheng, X. ; Zhou, Q. ; Villanueva, N. ; Nian, W. ; Liu, X. ; Huan, T. Metabolomics-Based Discovery Of Molecular Signatures For Triple Negative Breast Cancer In Asian Female Population. SCIENTIFIC REPORTS 2020, 10, 370.
Tang, X. ; Kudo, Y. ; Baker, J. L. ; LaBonte, S. ; Jordan, P. A. ; McKinnie, S. M. K. ; Guo, J. ; Huan, T. ; Moore, B. S. ; Edlund, A. Cariogenic Streptococcus Mutans Produces Tetramic Acid Strain-Specific Antibiotics That Impair Commensal Colonization. ACS INFECTIOUS DISEASES 2020, 6, 563-571.
Zhang, J. Jia; Tang, X. ; Huan, T. ; Ross, A. C. ; Moore, B. S. Avant-Garde Assembly-Line Biosynthesis Expands Diversity Of Cyclic Lipodepsipeptide Products. MARINE DRUGS 2020, 18.
Yang, J. J. ; Han, Y. ; Mah, C. H. ; Wanjaya, E. ; Peng, B. ; Xu, T. F. ; Liu, M. ; Huan, T. ; Fang, M. L. Streamlined Mrm Method Transfer Between Instruments Assisted With Hrms Matching And Retention-Time Prediction. ANALYTICA CHIMICA ACTA 2020, 1100, 88-96.
Zhang, J. Jia; Tang, X. ; Huan, T. ; Ross, A. C. ; Moore, B. S. Pass-Back Chain Extension Expands Multimodular Assembly Line Biosynthesis. NATURE CHEMICAL BIOLOGY 2020, 16, 42+.
Dong, Y. ; Arif, A. A. ; Guo, J. ; Ha, Z. ; Lee-Sayer, S. S. M. ; Poon, G. F. T. ; Dosanjh, M. ; Roskelley, C. D. ; Huan, T. ; Johnson, P. Cd44 Loss Disrupts Lung Lipid Surfactant Homeostasis And Exacerbates Oxidized Lipid-Induced Lung Inflammation. FRONTIERS IN IMMUNOLOGY 2020, 11, 29.
Li, L. ; Zheng, X. ; Zhou, Q. ; Villanueva, N. ; Nian, W. ; Liu, X. ; Huan, T. Metabolomics-Based Discovery Of Molecular Signatures For Triple Negative Breast Cancer In Asian Female Population. SCIENTIFIC REPORTS 2020, 10, 370.
Zhang, J. Jia; Tang, X. ; Huan, T. ; Ross, A. C. ; Moore, B. S. Avant-Garde Assembly-Line Biosynthesis Expands Diversity Of Cyclic Lipodepsipeptide Products. MARINE DRUGS 2020, 18.
Zhang, J. Jia; Tang, X. ; Huan, T. ; Ross, A. C. ; Moore, B. S. Pass-Back Chain Extension Expands Multimodular Assembly Line Biosynthesis. NATURE CHEMICAL BIOLOGY 2020, 16, 42+.

2019

Jia, S. ; Xu, T. ; Huan, T. ; Chong, M. ; Liu, M. ; Fang, W. ; Fang, M. Chemical Isotope Labeling Exposome (Cil-Exposome): One High-Throughput Platform For Human Urinary Global Exposome Characterization. Environmental science & technology 2019, 53, 5445–5453.
Hu, Y. ; Cai, B. ; Huan, T. Enhancing Metabolome Coverage In Data-Dependent Lc-Ms/ms Analysis Through An Integrated Feature Extraction Strategy. ANALYTICAL CHEMISTRY 2019, 91, 14433-14441.
Gimple, R. C. ; Kidwell, R. L. ; Kim, L. J. Y. ; Sun, T. ; Gromovsky, A. D. ; Wu, Q. ; Wolf, M. ; Lv, D. ; Bhargava, S. ; Jiang, L. ; Prager, B. C. ; Wang, X. ; Ye, Q. ; Zhu, Z. ; Zhang, G. ; Dong, Z. ; Zhao, L. ; Lee, D. ; Bi, J. ; Sloan, A. E. ; Mischel, P. S. ; J Brown, M. ; Cang, H. ; Huan, T. ; Mack, S. C. ; Xie, Q. ; Rich, J. N. Glioma Stem Cell Specific Super Enhancer Promotes Polyunsaturated Fatty Acid Synthesis To Support Egfr Signaling. Cancer discovery 2019, CD–19.
Gimple, R. C. ; Kidwell, R. L. ; Kim, L. J. Y. ; Sun, T. ; Gromovsky, A. D. ; Wu, Q. ; Wolf, M. ; Lv, D. ; Bhargava, S. ; Jiang, L. ; Prager, B. C. ; Wang, X. ; Ye, Q. ; Zhu, Z. ; Zhang, G. ; Dong, Z. ; Zhao, L. ; Lee, D. ; Bi, J. ; Sloan, A. E. ; Mischel, P. S. ; J. Brown, M. ; Cang, H. ; Huan, T. ; Mack, S. C. ; Xie, Q. ; Rich, J. N. Glioma Stem Cell-Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis To Support Egfr Signaling. CANCER DISCOVERY 2019, 9, 1248-1267.
Zhang, J. Jia; Tang, X. ; Huan, T. ; Ross, A. C. ; Moore, B. S. Pass-Back Chain Extension Expands Multimodular Assembly Line Biosynthesis. Nature chemical biology 2019, 1–8.
Jia, S. ; Xu, T. ; Huan, T. ; Chong, M. ; Liu, M. ; Fang, W. ; Fang, M. Chemical Isotope Labeling Exposome (Cil-Exposome): One High-Throughput Platform For Human Urinary Global Exposome Characterization. ENVIRONMENTAL SCIENCE & TECHNOLOGY 2019, 53, 5445-5453.
Hu, Y. ; Cai, B. ; Huan, T. Enhancing Metabolome Coverage In Data-Dependent Lc-Ms/ms Analysis Through An Integrated Feature Extraction Strategy. Analytical Chemistry 2019.
Hu, Y. ; Cai, B. ; Huan, T. Enhancing Metabolome Coverage In Data-Dependent Lc-Ms/ms Analysis Through An Integrated Feature Extraction Strategy. ANALYTICAL CHEMISTRY 2019, 91, 14433-14441.
Gimple, R. C. ; Kidwell, R. L. ; Kim, L. J. Y. ; Sun, T. ; Gromovsky, A. D. ; Wu, Q. ; Wolf, M. ; Lv, D. ; Bhargava, S. ; Jiang, L. ; Prager, B. C. ; Wang, X. ; Ye, Q. ; Zhu, Z. ; Zhang, G. ; Dong, Z. ; Zhao, L. ; Lee, D. ; Bi, J. ; Sloan, A. E. ; Mischel, P. S. ; J. Brown, M. ; Cang, H. ; Huan, T. ; Mack, S. C. ; Xie, Q. ; Rich, J. N. Glioma Stem Cell-Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis To Support Egfr Signaling. CANCER DISCOVERY 2019, 9, 1248-1267.
Jia, S. ; Xu, T. ; Huan, T. ; Chong, M. ; Liu, M. ; Fang, W. ; Fang, M. Chemical Isotope Labeling Exposome (Cil-Exposome): One High-Throughput Platform For Human Urinary Global Exposome Characterization. ENVIRONMENTAL SCIENCE & TECHNOLOGY 2019, 53, 5445-5453.

2018

Lee, C. - C. ; Hsieh, Y. - J. ; Chen, S. - W. ; Fu, S. - H. ; Hsu, C. - W. ; Wu, C. - C. ; Han, W. ; Li, Y. ; Huan, T. ; Chang, Y. - S. ; Yu, J. - S. ; Li, L. ; Chang, C. - H. ; Chen, Y. - T. Bretschneider Solution-Induced Alterations In The Urine Metabolome In Cardiac Surgery Patients. SCIENTIFIC REPORTS 2018, 8, 17774.
Sapkota, S. ; Huang, T. ; Tran, T. ; Zheng, J. ; Camicioli, R. ; Li, L. ; Dixon, R. A. Alzheimer's Biomarkers From Multiple Modalities Selectively Discriminate Clinical Status: Relative Importance Of Salivary Metabolomics Panels, Genetic, Lifestyle, Cognitive, Functional Health And Demographic Risk Markers. FRONTIERS IN AGING NEUROSCIENCE 2018, 10, 296.
Huan, T. ; Palermo, A. ; Ivanisevic, J. ; Rinehart, D. ; Edler, D. ; Phommavongsay, T. ; H. Benton, P. ; Guijas, C. ; Domingo-Almenara, X. ; Warth, B. ; Siuzdak, G. Autonomous Multimodal Metabolomics Data Integration For Comprehensive Pathway Analysis And Systems Biology. ANALYTICAL CHEMISTRY 2018, 90, 8396-8403.
Forsberg, E. M. ; Huan, T. ; Rinehart, D. ; H. Benton, P. ; Warth, B. ; Hilmers, B. ; Siuzdak, G. Data Processing, Multi-Omic Pathway Mapping, And Metabolite Activity Analysis Using Xcms Online. NATURE PROTOCOLS 2018, 13, 633-651.
Lee, C. - C. ; Hsieh, Y. - J. ; Chen, S. - W. ; Fu, S. - H. ; Hsu, C. - W. ; Wu, C. - C. ; Han, W. ; Li, Y. ; Huan, T. ; Chang, Y. - S. ; Yu, J. - S. ; Li, L. ; Chang, C. - H. ; Chen, Y. - T. Bretschneider Solution-Induced Alterations In The Urine Metabolome In Cardiac Surgery Patients. SCIENTIFIC REPORTS 2018, 8, 17774.
Warth, B. ; Raffeiner, P. ; Granados, A. ; Huan, T. ; Fang, M. ; Forsberg, E. M. ; H. Benton, P. ; Goetz, L. ; Johnson, C. H. ; Siuzdak, G. Metabolomics Reveals That Dietary Xenoestrogens Alter Cellular Metabolism Induced By Palbociclib/letrozole Combination Cancer Therapy. CELL CHEMICAL BIOLOGY 2018, 25, 291+.
Sapkota, S. ; Huang, T. ; Tran, T. ; Zheng, J. ; Camicioli, R. ; Li, L. ; Dixon, R. A. Alzheimer's Biomarkers From Multiple Modalities Selectively Discriminate Clinical Status: Relative Importance Of Salivary Metabolomics Panels, Genetic, Lifestyle, Cognitive, Functional Health And Demographic Risk Markers. FRONTIERS IN AGING NEUROSCIENCE 2018, 10, 296.
Guijas, C. ; J. Montenegro-Burke, R. ; Domingo-Almenara, X. ; Palermo, A. ; Warth, B. ; Hermann, G. ; Koellensperger, G. ; Huan, T. ; Uritboonthai, W. ; Aisporna, A. E. ; Wolan, D. W. ; Spilker, M. E. ; H. Benton, P. ; Siuzdak, G. Metlin: A Technology Platform For Identifying Knowns And Unknowns. ANALYTICAL CHEMISTRY 2018, 90, 3156-3164.
Huan, T. ; Palermo, A. ; Ivanisevic, J. ; Rinehart, D. ; Edler, D. ; Phommavongsay, T. ; H. Benton, P. ; Guijas, C. ; Domingo-Almenara, X. ; Warth, B. ; Siuzdak, G. Autonomous Multimodal Metabolomics Data Integration For Comprehensive Pathway Analysis And Systems Biology. ANALYTICAL CHEMISTRY 2018, 90, 8396-8403.
Huan, T. ; Tran, T. ; Zheng, J. ; Sapkota, S. ; MacDonald, S. W. ; Camicioli, R. ; Dixon, R. A. ; Li, L. Metabolomics Analyses Of Saliva Detect Novel Biomarkers Of Alzheimer's Disease. JOURNAL OF ALZHEIMERS DISEASE 2018, 65, 1401-1416.
Forsberg, E. M. ; Huan, T. ; Rinehart, D. ; H. Benton, P. ; Warth, B. ; Hilmers, B. ; Siuzdak, G. Data Processing, Multi-Omic Pathway Mapping, And Metabolite Activity Analysis Using Xcms Online. NATURE PROTOCOLS 2018, 13, 633-651.
Warth, B. ; Raffeiner, P. ; Granados, A. ; Huan, T. ; Fang, M. ; Forsberg, E. M. ; H. Benton, P. ; Goetz, L. ; Johnson, C. H. ; Siuzdak, G. Metabolomics Reveals That Dietary Xenoestrogens Alter Cellular Metabolism Induced By Palbociclib/letrozole Combination Cancer Therapy. CELL CHEMICAL BIOLOGY 2018, 25, 291+.
Guijas, C. ; J. Montenegro-Burke, R. ; Domingo-Almenara, X. ; Palermo, A. ; Warth, B. ; Hermann, G. ; Koellensperger, G. ; Huan, T. ; Uritboonthai, W. ; Aisporna, A. E. ; Wolan, D. W. ; Spilker, M. E. ; H. Benton, P. ; Siuzdak, G. Metlin: A Technology Platform For Identifying Knowns And Unknowns. ANALYTICAL CHEMISTRY 2018, 90, 3156-3164.
Warth, B. ; Raffeiner, P. ; Granados, A. ; Huan, T. ; Fang, M. ; Forsberg, E. M. ; H Benton, P. ; Goetz, L. ; Johnson, C. H. ; Siuzdak, G. Metabolomics Reveals That Dietary Xenoestrogens Alter Cellular Metabolism Induced By Palbociclib/letrozole Combination Cancer Therapy. Cell chemical biology 2018.
Huan, T. ; Tran, T. ; Zheng, J. ; Sapkota, S. ; MacDonald, S. W. ; Camicioli, R. ; Dixon, R. A. ; Li, L. Metabolomics Analyses Of Saliva Detect Novel Biomarkers Of Alzheimer's Disease. JOURNAL OF ALZHEIMERS DISEASE 2018, 65, 1401-1416.
Guijas, C. ; J Montenegro-Burke, R. ; Domingo-Almenara, X. ; Palermo, A. ; Warth, B. ; Hermann, G. ; Koellensperger, G. ; Huan, T. ; Uritboonthai, W. ; Aisporna, A. E. ; , Metlin: A Technology Platform For Identifying Knowns And Unknowns. Analytical chemistry 2018.
Forsberg, E. M. ; Huan, T. ; Rinehart, D. ; H Benton, P. ; Warth, B. ; Hilmers, B. ; Siuzdak, G. ; Wolan, D. W. ; Spiker, M. E. ; Benton, H. P. ; Siuzdak, G. Data Processing, Multi-Omic Pathway Mapping, And Metabolite Activity Analysis Using Xcms Online. Nature protocols 2018, 13, 633-651.
Huan, T. ; Tran, T. ; Zheng, J. ; Sapkota, S. ; MacDonald, S. W. ; Camicioli, R. ; Dixon, R. A. ; Li, L. Metabolomics Analyses Of Saliva Detect Novel Biomarkers Of Alzheimer’S Disease. Journal of Alzheimer's Disease 2018, 1–16.
Huan, T. ; Palermo, A. ; Ivanisevic, J. ; Rinehart, D. ; Edler, D. ; Phommavongsay, T. ; H Benton, P. ; Guijas, C. ; Domingo-Almenara, X. ; Warth, B. ; , Autonomous Multimodal Metabolomics Data Integration For Comprehensive Pathway Analysis And Systems Biology. Analytical chemistry 2018, 90, 8396–8403.
Sapkota, S. ; Huan, T. ; Tran, T. ; Zheng, J. ; Camicioli, R. ; Li, L. ; Dixon, R. A. Alzheimer’S Biomarkers From Multiple Modalities Selectively Discriminate Clinical Status: Relative Importance Of Salivary Metabolomics Panels, Genetic, Lifestyle, Cognitive, Functional Health, And Demographic Risk Markers. Frontiers in aging neuroscience 2018, 10, 296.
Lee, C. - C. ; Hsieh, Y. - J. ; Chen, S. - W. ; Fu, S. - H. ; Hsu, C. - W. ; Wu, C. - C. ; Han, W. ; Li, Y. ; Huan, T. ; Chang, Y. - S. ; , Bretschneider Solution-Induced Alterations In The Urine Metabolome In Cardiac Surgery Patients. Scientific reports 2018, 8, 17774.

2017

Warth, B. ; Spangler, S. ; Fang, M. ; Johnson, C. H. ; Forsberg, E. M. ; Granados, A. ; Martin, R. L. ; Domingo-Almenara, X. ; Huan, T. ; Rinehart, D. ; J. Montenegro-Burke, R. ; Hilmers, B. ; Aisporna, A. ; Hoang, L. T. ; Uritboonthai, W. ; H. Benton, P. ; Richardson, S. D. ; Williams, A. J. ; Siuzdak, G. Exposome-Scale Investigations Guided By Global Metabolomics, Pathway Analysis, And Cognitive Computing. ANALYTICAL CHEMISTRY 2017, 89, 11505-11513.
Huan, T. ; Forsberg, E. M. ; Rinehart, D. ; Johnson, C. H. ; Ivanisevic, J. ; H. Benton, P. ; Fang, M. ; Aisporna, A. ; Hilmers, B. ; Poole, F. L. ; Thorgersen, M. P. ; Adams, M. W. W. ; Krantz, G. ; Fields, M. W. ; Robbins, P. D. ; Niedernhofer, L. J. ; Ideker, T. ; Majumder, E. L. ; Wall, J. D. ; Rattray, N. J. W. ; Goodacre, R. ; Lairson, L. L. ; Siuzdak, G. Systems Biology Guided By Xcms Online Metabolomics. NATURE METHODS 2017, 14, 461-462.
J. Montenegro-Burke, R. ; Aisporna, A. E. ; H. Benton, P. ; Rinehart, D. ; Fang, M. ; Huan, T. ; Warth, B. ; Forsberg, E. ; Abe, B. T. ; Iyanisevic, J. ; Wolan, D. W. ; Teyton, L. ; Lairson, L. ; Siuzdak, G. Data Streaming For Metabolomics: Accelerating Data Processing And Analysis From Days To Minutes. ANALYTICAL CHEMISTRY 2017, 89, 1254-1259.
Liu, S. ; Zhang, C. ; Su, Q. ; Li, L. ; Su, J. ; Huang, T. ; Chen, Y. ; Yu, A. Enhancing Electrochemical Performance Of Lini0.6Co0.2Mn0.2O2 By Lithium-Ion Conductor Surface Modification. ELECTROCHIMICA ACTA 2017, 224, 171-177.

2016

J. Montenegro-Burke, R. ; Phommavongsay, T. ; Aisporna, A. E. ; Huan, T. ; Rinehart, D. ; Forsberg, E. ; Poole, F. L. ; Thorgersen, M. P. ; Adams, M. W. W. ; Krantz, G. ; Fields, M. W. ; Northen, T. R. ; Robbins, P. D. ; Niedernhofer, L. J. ; Lairson, L. ; H. Benton, P. ; Siuzdak, G. Smartphone Analytics: Mobilizing The Lab Into The Cloud For Omicscale Analyses. ANALYTICAL CHEMISTRY 2016, 88, 9753-9758.
Huan, T. ; Troyer, D. A. ; Li, L. Metabolite Analysis And Histology On The Exact Same Tissue: Comprehensive Metabolomic Profiling And Metabolic Classification Of Prostate Cancer. SCIENTIFIC REPORTS 2016, 6, 32272.
Luo, X. ; Zhao, S. ; Huan, T. ; Sun, D. ; R. Friis, M. N. ; Schultz, M. C. ; Li, L. High-Performance Chemical Isotope Labeling Liquid Chromatography Mass Spectrometry For Profiling The Metabolomic Reprogramming Elicited By Ammonium Limitation In Yeast. JOURNAL OF PROTEOME RESEARCH 2016, 15, 1602-1612.
Geng, S. ; Zhou, C. ; Chen, W. ; Yu, S. ; Huang, W. ; Huan, T. ; Xu, J. ; Yan, X. Fatty Acid And Sterol Composition Reveal Food Selectivity Of Juvenile Ark Shell Tegillarca Granosa Linnaeus After Feeding With Mixed Microalgae. AQUACULTURE 2016, 455, 109-117.
Su, X. ; Wang, N. ; Chen, D. ; Li, Y. ; Lu, Y. ; Huan, T. ; Xu, W. ; Li, L. ; Li, L. Dansylation Isotope Labeling Liquid Chromatography Mass Spectrometry For Parallel Profiling Of Human Urinary And Fecal Submetabolomes. ANALYTICA CHIMICA ACTA 2016, 903, 100-109.
Zhao-Kun, Z. ; Zhen-Yu, Y. ; Huan, T. ; Ming, Z. High-Efficiency Wavefront Control With Based On Helical Metamaterials. ACTA PHYSICA SINICA 2016, 65, 217802.
Huan, T. ; Xian, J. Wen; Leung, W. Nang; Li, L. ; Chan, C. Wai Cerebrospinal Fluid Metabolomics After Natural Product Treatment In An Experimental Model Of Cerebral Ischemia. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY 2016, 20, 670-680.

2015

Huan, T. ; Tang, C. ; Li, R. ; Shi, Y. ; Lin, G. ; Li, L. Mycompoundid Ms/ms Search: Metabolite Identification Using A Library Of Predicted Fragment-Ion-Spectra Of 383,830 Possible Human Metabolites. ANALYTICAL CHEMISTRY 2015, 87, 10619-10626.
Huan, T. ; Wu, Y. ; Tang, C. ; Lin, G. ; Li, L. Dnsid In Mycompoundid For Rapid Identification Of Dansylated Amine- And Phenol-Containing Metabolites In Lc-Ms-Based Metabolomics. ANALYTICAL CHEMISTRY 2015, 87, 9838-9845.
Huan, T. ; Li, L. Quantitative Metabolome Analysis Based On Chromatographic Peak Reconstruction In Chemical Isotope Labeling Liquid Chromatography Mass Spectrometry. ANALYTICAL CHEMISTRY 2015, 87, 7011-7016.
Zhou, R. ; Huan, T. ; Li, L. Development Of Versatile Isotopic Labeling Reagents For Profiling The Amine Submetabolome By Liquid Chromatography-Mass Spectrometry. ANALYTICA CHIMICA ACTA 2015, 881, 107-116.
Xu, W. ; Chen, D. ; Wang, N. ; Zhang, T. ; Zhou, R. ; Huan, T. ; Lu, Y. ; Su, X. ; Xie, Q. ; Li, L. ; Li, L. Development Of High-Performance Chemical Isotope Labeling Lc-Ms For Profiling The Human Fecal Metabolome. ANALYTICAL CHEMISTRY 2015, 87, 829-836.
Huan, T. ; Li, L. Counting Missing Values In A Metabolite-Intensity Data Set For Measuring The Analytical Performance Of A Metabolomics Platform. ANALYTICAL CHEMISTRY 2015, 87, 1306-1313.

2014

Zhou, R. ; Tseng, C. - L. ; Huan, T. ; Li, L. Isoms: Automated Processing Of Lc-Ms Data Generated By A Chemical Isotope Labeling Metabolomics Platform. ANALYTICAL CHEMISTRY 2014, 86, 4675-4679.
R. Friis, M. N. ; Glaves, J. Paul; Huan, T. ; Li, L. ; Sykes, B. D. ; Schultz, M. C. Rewiring Ampk And Mitochondrial Retrograde Signaling For Metabolic Control Of Aging And Histone Acetylation In Respiratory-Defective Cells. CELL REPORTS 2014, 7, 565-574.
Dimopoulos, I. ; Huan, T. ; Li, L. ; Sauve, Y. Application Of Stable Isotope-Assisted Metabolomics In Neovascular (Wet) Age-Related Macular Degeneration (Amd). INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 2014, 55.

2013

Li, L. ; Li, R. ; Zhou, J. ; Zuniga, A. ; Stanislaus, A. E. ; Wu, Y. ; Huan, T. ; Zheng, J. ; Shi, Y. ; Wishart, D. S. ; Lin, G. Mycompoundid: Using An Evidence-Based Metabolome Library For Metabolite Identification. ANALYTICAL CHEMISTRY 2013, 85, 3401-3408.