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  3. Tao Huan

Tao Huan

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Research and Teaching Interests

Metabolomics is an omics biotechnology. It profiles the complete set of small molecules in biological and environmental systems. These molecules provide a direct readout of metabolism, exposure, physiology, and disease state, making metabolomics one of the most powerful omics approaches in the post-genome era. Mass spectrometry (MS) is an excellent analytical platform for metabolomics, as it is highly sensitive, reproducible, and versatile. It measures the masses of metabolites and their fragments to assist in elucidating their structures. The Huan Lab integrates chemistry, biology, computer science, and environmental science to advance mass spectrometry-based metabolomics for the comprehensive, sensitive, and high-throughput detection, quantification, and characterization of small-molecule chemicals in complex biological and environmental systems.

Ongoing research projects include:

  • Analytical method development: Improve metabolite stability, sample preparation, and mass spectrometry methods for sensitive and reliable metabolomic measurements.
  • Computational metabolomics: Develop algorithms and cloud-based tools for chromatographic peak processing, correction of quantitative biases, and metabolomics data analysis.
  • AI-driven chemical discovery: Apply machine learning to predict molecular fragmentation, annotate compounds, and discover unknown metabolites and environmental chemicals.
  • Environmental metabolomics and exposomics
    • Water quality: Develop exposomics methods to discover and characterize disinfection byproducts and other overlooked chemicals in water.
    • Environmental exposures: Use hair and urine analysis to investigate occupational exposures, environmental pollution, and PFAS.
    • Chemical transformations: Investigate how chemicals degrade, react, and form new products during sample preparation and environmental treatment.
  • Biological metabolomics
    • Lipid metabolism: Develop metabolic flux analysis to investigate how lipids are synthesized, transformed, and utilized.
    • Maternal nutrition and development: Examine how maternal sugar overconsumption affects metabolism in pregnant animals and their offspring.
    • Systems biology: Connect metabolomic measurements with other molecular data to investigate relationships between metabolic changes and biological function.
  • Clinical metabolomics and toxicology
    • Organ transplantation: Discover metabolic and multi-omic biomarkers for early detection of acute cellular rejection and cardiac allograft vasculopathy.
    • Cancer detection: Identify and validate urinary metabolic biomarkers for early-stage bladder cancer diagnosis.
    • Drug poisoning: Investigate the chemical composition of the unregulated opioid supply and its relationship to clinical and toxicological outcomes.

Highly motivated students interested in pursuing graduate studies in our research areas are encouraged to contact Dr. Huan (thuan@chem.ubc.ca) during the application process. 

To apply online:

https://www.grad.ubc.ca/prospective-students/application-admission/apply-online

Contact

Real name: 
Tao Huan
Email: 
Office Room Number(s): 
D214
Office Phone Number: 
604-822-4891
Lab Room: 
E111
Lab Phone: 
604-827-2196

Curriculum Vitae

Postdoctoral Research Associate, The Scripps Research Institute (La Jolla), USA (2015 - 2018)

Ph.D., Analytical Chemistry, University of Alberta, Canada (2010 - 2015)

B.Sc., Chemistry, Zhejiang University, China (2006 - 2010)

Publications

2026

Yu, H. ; Biswas, P. ; Rideout, E. ; Cao, Y. ; Fiehn, O. ; Huan, T. Bago: A Self-Optimizing Tool For Lc-Ms Gradient Design In Metabolomics. Analytical Chemistry 2026, 98, 18660–18672.
Low, B. ; Nguyen, C. ; Huan, T. The Multifaceted Challenge Of Normalizing Mass Spectrometry-Based Metabolomics Data. Analytical Chemistry 2026, 98, 13967–13974.
Huan, T. ; Li, X. Disinfection Byproducts In The Long-Tail Exposome: Unmet Challenges For Water Quality And Human Health. Environmental Science & Technology 2026, 60, 13255–13258.
Espín, E. ; Yang, C. ; Shannon, C. P. ; Checkervarty, A. K. ; Kim, S. ; Lapp, L. ; Assadian, S. ; Grunau, B. ; Goldfarb, D. M. ; Hutton, J. ; Huan, T. ; Tebbutt, S. J. Pilot Longitudinal Integrated Transcriptomic–Metabolomic Study Reveals Immune And Metabolic Signatures In Non-Hospitalized Healthcare Workers With Long Covid. Frontiers in Cellular and Infection Microbiology 2026, 16, 1808564.
Yang, C. ; Shannon, C. P. ; Assadian, S. ; Hui, A. ; Checkervarty, A. ; Zheng, A. ; Kim, E. ; Espín, E. ; Rajasekaran, A. ; Toma, M. ; Huan, T. ; Tebbutt, S. J. Metabolomic Biomarkers Predict Early Cardiac Allograft Vasculopathy: A Pilot Study. The Journal of Heart and Lung Transplantation 2026, 45, 73.

2025

Zhao, T. ; Shen, Q. ; Li, X. ; Huan, T. Iodofinder: Machine Learning-Guided Recognition Of Iodinated Chemicals In Nontargeted Lc-Ms/ms Analysis. Environmental Science & Technology 2025, 59, 4530–4539.
Kim, E. ; Huan, T. Disentangling Method-Induced Differences In Metabolomics: Single- Versus Dual-Phase Extraction. Analyst 2025, 151, 2842–2851.
Zhao, C. ; Zhao, T. ; Shen, Q. ; Tang, Z. ; Li, X. ; Huan, T. Practical Guidance For Training Machine Learning Models In Metabolomics And Mass Spectrometry Research. Analytical Chemistry 2025, 97, 23005–23013.
Liu, B. ; Tang, Z. ; Huan, T. Adduct-Induced Variability In Tandem Mass Spectrometry. Analytical Chemistry 2025, 97, 17058–17066.
Low, B. ; Zhao, T. ; Li, X. ; Huan, T. Machine Learning-Assisted Recognition Of Environmental Sulfur-Containing Chemicals In Non-Targeted Mass Spectrometry Analysis Of Inadequate Mass Resolution. ACS Environmental Au 2025, 5, 573–582.
Zhao, T. ; Low, B. ; Shen, Q. ; Wang, Y. ; Delgado, D. H. ; Chau, K. N. M. ; Pang, Z. ; Li, X. ; Xia, J. ; Li, X. ; Huan, T. Exposome-Scale Investigation Of Cl-/br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multi-Stage Machine Learning, And Cloud Computing. Analytical Chemistry 2025.
Lee, K. ; Su, X. ; Huan, T. Metabolites Are Not Genes – Avoiding The Misuse Of Pathway Analysis In Metabolomics. Nature Metabolism 2025, 7, 858–861.

2024

Chen, Y. ; Wang, Y. ; Delgado, D. ; Yu, H. ; Zhao, T. ; Fang, M. ; Huan, T. Constructing Hairdb To Facilitate Exposome Research Using Human Hair. Environment International 2024, 109077.
Low, B. ; Wang, Y. ; Zhao, T. ; Yu, H. ; Huan, T. Closing The Knowledge Gap Of Post-Acquisition Sample Normalization In Untargeted Metabolomics. ACS Measurement Science Au 2024, 4, 702–711.
Wang, Y. ; Tang, Z. ; Zhao, T. ; Yang, J. ; Zhang, W. ; Li, X. ; Huan, T. Breathxplorer: Processing Online Breathomics Data Generated From Direct Analysis Using High-Resolution Mass Spectrometry. Journal of the American Society for Mass Spectrometry 2024, 35, 1818–1825.
Zhang, Z. ; Yu, H. ; Wong-Ma, E. ; Dokouhaki, P. ; Mostafa, A. ; Shavadia, J. ; Wu, F. ; Huan, T. Reducing Quantitative Uncertainty Caused By Data Processing In Untargeted Metabolomics. Analytical Chemistry 2024, 96, 3727–3732.

2023

Zhao, T. ; Xing, S. ; Yu, H. ; Huan, T. De Novo Cleaning Of Chimeric Ms/ms Spectra For Lc-Ms/ms-Based Metabolomics. Analytical Chemistry 2023, 95, 13018–13028.
Xing, S. ; Shen, S. ; Xu, B. ; Li, X. ; Huan, T. Buddy: Molecular Formula Discovery Via Bottom-Up Ms/ms Interrogation. Nature Methods 2023, 20, 881–890.

2022

Guo, J. ; Yu, H. ; Xing, S. ; Huan, T. Addressing Big Data Challenges In Mass Spectrometry-Based Metabolomics. Chemical Communications 2022, 58, 9979–9990.
Guo, J. ; Shen, S. ; Huan, T. Paramounter: Direct Measurement Of Universal Parameters To Process Metabolomics Data In A ``white Box''. Analytical Chemistry 2022, 94, 4260–4268.

2020

Li, L. ; Zheng, X. ; Zhou, Q. ; Villanueva, N. ; Nian, W. ; Liu, X. ; Huan, T. Metabolomics-Based Discovery Of Molecular Signatures For Triple Negative Breast Cancer In Asian Female Population. SCIENTIFIC REPORTS 2020, 10, 370.
Tang, X. ; Kudo, Y. ; Baker, J. L. ; LaBonte, S. ; Jordan, P. A. ; McKinnie, S. M. K. ; Guo, J. ; Huan, T. ; Moore, B. S. ; Edlund, A. Cariogenic Streptococcus Mutans Produces Tetramic Acid Strain-Specific Antibiotics That Impair Commensal Colonization. ACS INFECTIOUS DISEASES 2020, 6, 563-571.
Zhang, J. Jia; Tang, X. ; Huan, T. ; Ross, A. C. ; Moore, B. S. Avant-Garde Assembly-Line Biosynthesis Expands Diversity Of Cyclic Lipodepsipeptide Products. MARINE DRUGS 2020, 18.
Yang, J. J. ; Han, Y. ; Mah, C. H. ; Wanjaya, E. ; Peng, B. ; Xu, T. F. ; Liu, M. ; Huan, T. ; Fang, M. L. Streamlined Mrm Method Transfer Between Instruments Assisted With Hrms Matching And Retention-Time Prediction. ANALYTICA CHIMICA ACTA 2020, 1100, 88-96.
Zhang, J. Jia; Tang, X. ; Huan, T. ; Ross, A. C. ; Moore, B. S. Pass-Back Chain Extension Expands Multimodular Assembly Line Biosynthesis. NATURE CHEMICAL BIOLOGY 2020, 16, 42+.
Dong, Y. ; Arif, A. A. ; Guo, J. ; Ha, Z. ; Lee-Sayer, S. S. M. ; Poon, G. F. T. ; Dosanjh, M. ; Roskelley, C. D. ; Huan, T. ; Johnson, P. Cd44 Loss Disrupts Lung Lipid Surfactant Homeostasis And Exacerbates Oxidized Lipid-Induced Lung Inflammation. FRONTIERS IN IMMUNOLOGY 2020, 11, 29.
Li, L. ; Zheng, X. ; Zhou, Q. ; Villanueva, N. ; Nian, W. ; Liu, X. ; Huan, T. Metabolomics-Based Discovery Of Molecular Signatures For Triple Negative Breast Cancer In Asian Female Population. SCIENTIFIC REPORTS 2020, 10, 370.
Zhang, J. Jia; Tang, X. ; Huan, T. ; Ross, A. C. ; Moore, B. S. Avant-Garde Assembly-Line Biosynthesis Expands Diversity Of Cyclic Lipodepsipeptide Products. MARINE DRUGS 2020, 18.
Zhang, J. Jia; Tang, X. ; Huan, T. ; Ross, A. C. ; Moore, B. S. Pass-Back Chain Extension Expands Multimodular Assembly Line Biosynthesis. NATURE CHEMICAL BIOLOGY 2020, 16, 42+.
Chen, D. ; Han, W. ; Huan, T. ; Li, L. ; Li, L. Effects Of Freeze-Thaw Cycles Of Blood Samples On High-Coverage Quantitative Metabolomics. ANALYTICAL CHEMISTRY 2020, 92, 9265-9272.
Guo, J. ; Huan, T. Comparison Of Full-Scan, Data-Dependent, And Data-Independent Acquisition Modes In Liquid Chromatography-Mass Spectrometry Based Untargeted Metabolomics. ANALYTICAL CHEMISTRY 2020, 92, 8072-8080.
Yu, H. ; Xing, S. ; Nierves, L. ; Lange, P. F. ; Huan, T. Fold-Change Compression: An Unexplored But Correctable Quantitative Bias Caused By Nonlinear Electrospray Ionization Responses In Untargeted Metabolomics. ANALYTICAL CHEMISTRY 2020, 92, 7011-7019.
Tang, X. ; Kudo, Y. ; Baker, J. L. ; LaBonte, S. ; Jordan, P. A. ; McKinnie, S. M. K. ; Guo, J. ; Huan, T. ; Moore, B. S. ; Edlund, A. Cariogenic Streptococcus Mutans Produces Tetramic Acid Strain-Specific Antibiotics That Impair Commensal Colonization. ACS INFECTIOUS DISEASES 2020, 6, 563-571.
Chen, D. ; Han, W. ; Huan, T. ; Li, L. ; Li, L. Effects Of Freeze-Thaw Cycles Of Blood Samples On High-Coverage Quantitative Metabolomics. ANALYTICAL CHEMISTRY 2020, 92, 9265-9272.
Yang, J. J. ; Han, Y. ; Mah, C. H. ; Wanjaya, E. ; Peng, B. ; Xu, T. F. ; Liu, M. ; Huan, T. ; Fang, M. L. Streamlined Mrm Method Transfer Between Instruments Assisted With Hrms Matching And Retention-Time Prediction. ANALYTICA CHIMICA ACTA 2020, 1100, 88-96.
Guo, J. ; Huan, T. Comparison Of Full-Scan, Data-Dependent, And Data-Independent Acquisition Modes In Liquid Chromatography-Mass Spectrometry Based Untargeted Metabolomics. ANALYTICAL CHEMISTRY 2020, 92, 8072-8080.
Dong, Y. ; Arif, A. A. ; Guo, J. ; Ha, Z. ; Lee-Sayer, S. S. M. ; Poon, G. F. T. ; Dosanjh, M. ; Roskelley, C. D. ; Huan, T. ; Johnson, P. Cd44 Loss Disrupts Lung Lipid Surfactant Homeostasis And Exacerbates Oxidized Lipid-Induced Lung Inflammation. FRONTIERS IN IMMUNOLOGY 2020, 11, 29.
Yu, H. ; Xing, S. ; Nierves, L. ; Lange, P. F. ; Huan, T. Fold-Change Compression: An Unexplored But Correctable Quantitative Bias Caused By Nonlinear Electrospray Ionization Responses In Untargeted Metabolomics. ANALYTICAL CHEMISTRY 2020, 92, 7011-7019.

2019

Hu, Y. ; Cai, B. ; Huan, T. Enhancing Metabolome Coverage In Data-Dependent Lc-Ms/ms Analysis Through An Integrated Feature Extraction Strategy. ANALYTICAL CHEMISTRY 2019, 91, 14433-14441.
Gimple, R. C. ; Kidwell, R. L. ; Kim, L. J. Y. ; Sun, T. ; Gromovsky, A. D. ; Wu, Q. ; Wolf, M. ; Lv, D. ; Bhargava, S. ; Jiang, L. ; Prager, B. C. ; Wang, X. ; Ye, Q. ; Zhu, Z. ; Zhang, G. ; Dong, Z. ; Zhao, L. ; Lee, D. ; Bi, J. ; Sloan, A. E. ; Mischel, P. S. ; J. Brown, M. ; Cang, H. ; Huan, T. ; Mack, S. C. ; Xie, Q. ; Rich, J. N. Glioma Stem Cell-Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis To Support Egfr Signaling. CANCER DISCOVERY 2019, 9, 1248-1267.
Jia, S. ; Xu, T. ; Huan, T. ; Chong, M. ; Liu, M. ; Fang, W. ; Fang, M. Chemical Isotope Labeling Exposome (Cil-Exposome): One High-Throughput Platform For Human Urinary Global Exposome Characterization. ENVIRONMENTAL SCIENCE & TECHNOLOGY 2019, 53, 5445-5453.
Jia, S. ; Xu, T. ; Huan, T. ; Chong, M. ; Liu, M. ; Fang, W. ; Fang, M. Chemical Isotope Labeling Exposome (Cil-Exposome): One High-Throughput Platform For Human Urinary Global Exposome Characterization. Environmental science & technology 2019, 53, 5445–5453.
Hu, Y. ; Cai, B. ; Huan, T. Enhancing Metabolome Coverage In Data-Dependent Lc-Ms/ms Analysis Through An Integrated Feature Extraction Strategy. ANALYTICAL CHEMISTRY 2019, 91, 14433-14441.
Gimple, R. C. ; Kidwell, R. L. ; Kim, L. J. Y. ; Sun, T. ; Gromovsky, A. D. ; Wu, Q. ; Wolf, M. ; Lv, D. ; Bhargava, S. ; Jiang, L. ; Prager, B. C. ; Wang, X. ; Ye, Q. ; Zhu, Z. ; Zhang, G. ; Dong, Z. ; Zhao, L. ; Lee, D. ; Bi, J. ; Sloan, A. E. ; Mischel, P. S. ; J Brown, M. ; Cang, H. ; Huan, T. ; Mack, S. C. ; Xie, Q. ; Rich, J. N. Glioma Stem Cell Specific Super Enhancer Promotes Polyunsaturated Fatty Acid Synthesis To Support Egfr Signaling. Cancer discovery 2019, CD–19.
Gimple, R. C. ; Kidwell, R. L. ; Kim, L. J. Y. ; Sun, T. ; Gromovsky, A. D. ; Wu, Q. ; Wolf, M. ; Lv, D. ; Bhargava, S. ; Jiang, L. ; Prager, B. C. ; Wang, X. ; Ye, Q. ; Zhu, Z. ; Zhang, G. ; Dong, Z. ; Zhao, L. ; Lee, D. ; Bi, J. ; Sloan, A. E. ; Mischel, P. S. ; J. Brown, M. ; Cang, H. ; Huan, T. ; Mack, S. C. ; Xie, Q. ; Rich, J. N. Glioma Stem Cell-Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis To Support Egfr Signaling. CANCER DISCOVERY 2019, 9, 1248-1267.
Zhang, J. Jia; Tang, X. ; Huan, T. ; Ross, A. C. ; Moore, B. S. Pass-Back Chain Extension Expands Multimodular Assembly Line Biosynthesis. Nature chemical biology 2019, 1–8.
Jia, S. ; Xu, T. ; Huan, T. ; Chong, M. ; Liu, M. ; Fang, W. ; Fang, M. Chemical Isotope Labeling Exposome (Cil-Exposome): One High-Throughput Platform For Human Urinary Global Exposome Characterization. ENVIRONMENTAL SCIENCE & TECHNOLOGY 2019, 53, 5445-5453.
Hu, Y. ; Cai, B. ; Huan, T. Enhancing Metabolome Coverage In Data-Dependent Lc-Ms/ms Analysis Through An Integrated Feature Extraction Strategy. Analytical Chemistry 2019.

2018

Guijas, C. ; J Montenegro-Burke, R. ; Domingo-Almenara, X. ; Palermo, A. ; Warth, B. ; Hermann, G. ; Koellensperger, G. ; Huan, T. ; Uritboonthai, W. ; Aisporna, A. E. ; , Metlin: A Technology Platform For Identifying Knowns And Unknowns. Analytical chemistry 2018.
Forsberg, E. M. ; Huan, T. ; Rinehart, D. ; H Benton, P. ; Warth, B. ; Hilmers, B. ; Siuzdak, G. ; Wolan, D. W. ; Spiker, M. E. ; Benton, H. P. ; Siuzdak, G. Data Processing, Multi-Omic Pathway Mapping, And Metabolite Activity Analysis Using Xcms Online. Nature protocols 2018, 13, 633-651.
Huan, T. ; Tran, T. ; Zheng, J. ; Sapkota, S. ; MacDonald, S. W. ; Camicioli, R. ; Dixon, R. A. ; Li, L. Metabolomics Analyses Of Saliva Detect Novel Biomarkers Of Alzheimer’S Disease. Journal of Alzheimer's Disease 2018, 1–16.
Huan, T. ; Palermo, A. ; Ivanisevic, J. ; Rinehart, D. ; Edler, D. ; Phommavongsay, T. ; H Benton, P. ; Guijas, C. ; Domingo-Almenara, X. ; Warth, B. ; , Autonomous Multimodal Metabolomics Data Integration For Comprehensive Pathway Analysis And Systems Biology. Analytical chemistry 2018, 90, 8396–8403.
Sapkota, S. ; Huan, T. ; Tran, T. ; Zheng, J. ; Camicioli, R. ; Li, L. ; Dixon, R. A. Alzheimer’S Biomarkers From Multiple Modalities Selectively Discriminate Clinical Status: Relative Importance Of Salivary Metabolomics Panels, Genetic, Lifestyle, Cognitive, Functional Health, And Demographic Risk Markers. Frontiers in aging neuroscience 2018, 10, 296.
Lee, C. - C. ; Hsieh, Y. - J. ; Chen, S. - W. ; Fu, S. - H. ; Hsu, C. - W. ; Wu, C. - C. ; Han, W. ; Li, Y. ; Huan, T. ; Chang, Y. - S. ; , Bretschneider Solution-Induced Alterations In The Urine Metabolome In Cardiac Surgery Patients. Scientific reports 2018, 8, 17774.
Lee, C. - C. ; Hsieh, Y. - J. ; Chen, S. - W. ; Fu, S. - H. ; Hsu, C. - W. ; Wu, C. - C. ; Han, W. ; Li, Y. ; Huan, T. ; Chang, Y. - S. ; Yu, J. - S. ; Li, L. ; Chang, C. - H. ; Chen, Y. - T. Bretschneider Solution-Induced Alterations In The Urine Metabolome In Cardiac Surgery Patients. SCIENTIFIC REPORTS 2018, 8, 17774.
Sapkota, S. ; Huang, T. ; Tran, T. ; Zheng, J. ; Camicioli, R. ; Li, L. ; Dixon, R. A. Alzheimer's Biomarkers From Multiple Modalities Selectively Discriminate Clinical Status: Relative Importance Of Salivary Metabolomics Panels, Genetic, Lifestyle, Cognitive, Functional Health And Demographic Risk Markers. FRONTIERS IN AGING NEUROSCIENCE 2018, 10, 296.
Huan, T. ; Palermo, A. ; Ivanisevic, J. ; Rinehart, D. ; Edler, D. ; Phommavongsay, T. ; H. Benton, P. ; Guijas, C. ; Domingo-Almenara, X. ; Warth, B. ; Siuzdak, G. Autonomous Multimodal Metabolomics Data Integration For Comprehensive Pathway Analysis And Systems Biology. ANALYTICAL CHEMISTRY 2018, 90, 8396-8403.
Forsberg, E. M. ; Huan, T. ; Rinehart, D. ; H. Benton, P. ; Warth, B. ; Hilmers, B. ; Siuzdak, G. Data Processing, Multi-Omic Pathway Mapping, And Metabolite Activity Analysis Using Xcms Online. NATURE PROTOCOLS 2018, 13, 633-651.
Lee, C. - C. ; Hsieh, Y. - J. ; Chen, S. - W. ; Fu, S. - H. ; Hsu, C. - W. ; Wu, C. - C. ; Han, W. ; Li, Y. ; Huan, T. ; Chang, Y. - S. ; Yu, J. - S. ; Li, L. ; Chang, C. - H. ; Chen, Y. - T. Bretschneider Solution-Induced Alterations In The Urine Metabolome In Cardiac Surgery Patients. SCIENTIFIC REPORTS 2018, 8, 17774.
Warth, B. ; Raffeiner, P. ; Granados, A. ; Huan, T. ; Fang, M. ; Forsberg, E. M. ; H. Benton, P. ; Goetz, L. ; Johnson, C. H. ; Siuzdak, G. Metabolomics Reveals That Dietary Xenoestrogens Alter Cellular Metabolism Induced By Palbociclib/letrozole Combination Cancer Therapy. CELL CHEMICAL BIOLOGY 2018, 25, 291+.
Sapkota, S. ; Huang, T. ; Tran, T. ; Zheng, J. ; Camicioli, R. ; Li, L. ; Dixon, R. A. Alzheimer's Biomarkers From Multiple Modalities Selectively Discriminate Clinical Status: Relative Importance Of Salivary Metabolomics Panels, Genetic, Lifestyle, Cognitive, Functional Health And Demographic Risk Markers. FRONTIERS IN AGING NEUROSCIENCE 2018, 10, 296.
Guijas, C. ; J. Montenegro-Burke, R. ; Domingo-Almenara, X. ; Palermo, A. ; Warth, B. ; Hermann, G. ; Koellensperger, G. ; Huan, T. ; Uritboonthai, W. ; Aisporna, A. E. ; Wolan, D. W. ; Spilker, M. E. ; H. Benton, P. ; Siuzdak, G. Metlin: A Technology Platform For Identifying Knowns And Unknowns. ANALYTICAL CHEMISTRY 2018, 90, 3156-3164.
Huan, T. ; Palermo, A. ; Ivanisevic, J. ; Rinehart, D. ; Edler, D. ; Phommavongsay, T. ; H. Benton, P. ; Guijas, C. ; Domingo-Almenara, X. ; Warth, B. ; Siuzdak, G. Autonomous Multimodal Metabolomics Data Integration For Comprehensive Pathway Analysis And Systems Biology. ANALYTICAL CHEMISTRY 2018, 90, 8396-8403.
Huan, T. ; Tran, T. ; Zheng, J. ; Sapkota, S. ; MacDonald, S. W. ; Camicioli, R. ; Dixon, R. A. ; Li, L. Metabolomics Analyses Of Saliva Detect Novel Biomarkers Of Alzheimer's Disease. JOURNAL OF ALZHEIMERS DISEASE 2018, 65, 1401-1416.
Forsberg, E. M. ; Huan, T. ; Rinehart, D. ; H. Benton, P. ; Warth, B. ; Hilmers, B. ; Siuzdak, G. Data Processing, Multi-Omic Pathway Mapping, And Metabolite Activity Analysis Using Xcms Online. NATURE PROTOCOLS 2018, 13, 633-651.
Warth, B. ; Raffeiner, P. ; Granados, A. ; Huan, T. ; Fang, M. ; Forsberg, E. M. ; H. Benton, P. ; Goetz, L. ; Johnson, C. H. ; Siuzdak, G. Metabolomics Reveals That Dietary Xenoestrogens Alter Cellular Metabolism Induced By Palbociclib/letrozole Combination Cancer Therapy. CELL CHEMICAL BIOLOGY 2018, 25, 291+.
Guijas, C. ; J. Montenegro-Burke, R. ; Domingo-Almenara, X. ; Palermo, A. ; Warth, B. ; Hermann, G. ; Koellensperger, G. ; Huan, T. ; Uritboonthai, W. ; Aisporna, A. E. ; Wolan, D. W. ; Spilker, M. E. ; H. Benton, P. ; Siuzdak, G. Metlin: A Technology Platform For Identifying Knowns And Unknowns. ANALYTICAL CHEMISTRY 2018, 90, 3156-3164.
Warth, B. ; Raffeiner, P. ; Granados, A. ; Huan, T. ; Fang, M. ; Forsberg, E. M. ; H Benton, P. ; Goetz, L. ; Johnson, C. H. ; Siuzdak, G. Metabolomics Reveals That Dietary Xenoestrogens Alter Cellular Metabolism Induced By Palbociclib/letrozole Combination Cancer Therapy. Cell chemical biology 2018.
Huan, T. ; Tran, T. ; Zheng, J. ; Sapkota, S. ; MacDonald, S. W. ; Camicioli, R. ; Dixon, R. A. ; Li, L. Metabolomics Analyses Of Saliva Detect Novel Biomarkers Of Alzheimer's Disease. JOURNAL OF ALZHEIMERS DISEASE 2018, 65, 1401-1416.

2017

Warth, B. ; Spangler, S. ; Fang, M. ; Johnson, C. H. ; Forsberg, E. M. ; Granados, A. ; Martin, R. L. ; Domingo-Almenara, X. ; Huan, T. ; Rinehart, D. ; J. Montenegro-Burke, R. ; Hilmers, B. ; Aisporna, A. ; Hoang, L. T. ; Uritboonthai, W. ; H. Benton, P. ; Richardson, S. D. ; Williams, A. J. ; Siuzdak, G. Exposome-Scale Investigations Guided By Global Metabolomics, Pathway Analysis, And Cognitive Computing. ANALYTICAL CHEMISTRY 2017, 89, 11505-11513.
Huan, T. ; Forsberg, E. M. ; Rinehart, D. ; Johnson, C. H. ; Ivanisevic, J. ; H. Benton, P. ; Fang, M. ; Aisporna, A. ; Hilmers, B. ; Poole, F. L. ; Thorgersen, M. P. ; Adams, M. W. W. ; Krantz, G. ; Fields, M. W. ; Robbins, P. D. ; Niedernhofer, L. J. ; Ideker, T. ; Majumder, E. L. ; Wall, J. D. ; Rattray, N. J. W. ; Goodacre, R. ; Lairson, L. L. ; Siuzdak, G. Systems Biology Guided By Xcms Online Metabolomics. NATURE METHODS 2017, 14, 461-462.
J. Montenegro-Burke, R. ; Aisporna, A. E. ; H. Benton, P. ; Rinehart, D. ; Fang, M. ; Huan, T. ; Warth, B. ; Forsberg, E. ; Abe, B. T. ; Iyanisevic, J. ; Wolan, D. W. ; Teyton, L. ; Lairson, L. ; Siuzdak, G. Data Streaming For Metabolomics: Accelerating Data Processing And Analysis From Days To Minutes. ANALYTICAL CHEMISTRY 2017, 89, 1254-1259.
Liu, S. ; Zhang, C. ; Su, Q. ; Li, L. ; Su, J. ; Huang, T. ; Chen, Y. ; Yu, A. Enhancing Electrochemical Performance Of Lini0.6Co0.2Mn0.2O2 By Lithium-Ion Conductor Surface Modification. ELECTROCHIMICA ACTA 2017, 224, 171-177.

2016

Zhao-Kun, Z. ; Zhen-Yu, Y. ; Huan, T. ; Ming, Z. High-Efficiency Wavefront Control With Based On Helical Metamaterials. ACTA PHYSICA SINICA 2016, 65, 217802.
Huan, T. ; Xian, J. Wen; Leung, W. Nang; Li, L. ; Chan, C. Wai Cerebrospinal Fluid Metabolomics After Natural Product Treatment In An Experimental Model Of Cerebral Ischemia. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY 2016, 20, 670-680.
J. Montenegro-Burke, R. ; Phommavongsay, T. ; Aisporna, A. E. ; Huan, T. ; Rinehart, D. ; Forsberg, E. ; Poole, F. L. ; Thorgersen, M. P. ; Adams, M. W. W. ; Krantz, G. ; Fields, M. W. ; Northen, T. R. ; Robbins, P. D. ; Niedernhofer, L. J. ; Lairson, L. ; H. Benton, P. ; Siuzdak, G. Smartphone Analytics: Mobilizing The Lab Into The Cloud For Omicscale Analyses. ANALYTICAL CHEMISTRY 2016, 88, 9753-9758.
Huan, T. ; Troyer, D. A. ; Li, L. Metabolite Analysis And Histology On The Exact Same Tissue: Comprehensive Metabolomic Profiling And Metabolic Classification Of Prostate Cancer. SCIENTIFIC REPORTS 2016, 6, 32272.
Luo, X. ; Zhao, S. ; Huan, T. ; Sun, D. ; R. Friis, M. N. ; Schultz, M. C. ; Li, L. High-Performance Chemical Isotope Labeling Liquid Chromatography Mass Spectrometry For Profiling The Metabolomic Reprogramming Elicited By Ammonium Limitation In Yeast. JOURNAL OF PROTEOME RESEARCH 2016, 15, 1602-1612.
Geng, S. ; Zhou, C. ; Chen, W. ; Yu, S. ; Huang, W. ; Huan, T. ; Xu, J. ; Yan, X. Fatty Acid And Sterol Composition Reveal Food Selectivity Of Juvenile Ark Shell Tegillarca Granosa Linnaeus After Feeding With Mixed Microalgae. AQUACULTURE 2016, 455, 109-117.
Su, X. ; Wang, N. ; Chen, D. ; Li, Y. ; Lu, Y. ; Huan, T. ; Xu, W. ; Li, L. ; Li, L. Dansylation Isotope Labeling Liquid Chromatography Mass Spectrometry For Parallel Profiling Of Human Urinary And Fecal Submetabolomes. ANALYTICA CHIMICA ACTA 2016, 903, 100-109.

2015

Huan, T. ; Li, L. Counting Missing Values In A Metabolite-Intensity Data Set For Measuring The Analytical Performance Of A Metabolomics Platform. ANALYTICAL CHEMISTRY 2015, 87, 1306-1313.
Huan, T. ; Tang, C. ; Li, R. ; Shi, Y. ; Lin, G. ; Li, L. Mycompoundid Ms/ms Search: Metabolite Identification Using A Library Of Predicted Fragment-Ion-Spectra Of 383,830 Possible Human Metabolites. ANALYTICAL CHEMISTRY 2015, 87, 10619-10626.
Huan, T. ; Wu, Y. ; Tang, C. ; Lin, G. ; Li, L. Dnsid In Mycompoundid For Rapid Identification Of Dansylated Amine- And Phenol-Containing Metabolites In Lc-Ms-Based Metabolomics. ANALYTICAL CHEMISTRY 2015, 87, 9838-9845.
Huan, T. ; Li, L. Quantitative Metabolome Analysis Based On Chromatographic Peak Reconstruction In Chemical Isotope Labeling Liquid Chromatography Mass Spectrometry. ANALYTICAL CHEMISTRY 2015, 87, 7011-7016.
Zhou, R. ; Huan, T. ; Li, L. Development Of Versatile Isotopic Labeling Reagents For Profiling The Amine Submetabolome By Liquid Chromatography-Mass Spectrometry. ANALYTICA CHIMICA ACTA 2015, 881, 107-116.
Xu, W. ; Chen, D. ; Wang, N. ; Zhang, T. ; Zhou, R. ; Huan, T. ; Lu, Y. ; Su, X. ; Xie, Q. ; Li, L. ; Li, L. Development Of High-Performance Chemical Isotope Labeling Lc-Ms For Profiling The Human Fecal Metabolome. ANALYTICAL CHEMISTRY 2015, 87, 829-836.

2014

Zhou, R. ; Tseng, C. - L. ; Huan, T. ; Li, L. Isoms: Automated Processing Of Lc-Ms Data Generated By A Chemical Isotope Labeling Metabolomics Platform. ANALYTICAL CHEMISTRY 2014, 86, 4675-4679.
R. Friis, M. N. ; Glaves, J. Paul; Huan, T. ; Li, L. ; Sykes, B. D. ; Schultz, M. C. Rewiring Ampk And Mitochondrial Retrograde Signaling For Metabolic Control Of Aging And Histone Acetylation In Respiratory-Defective Cells. CELL REPORTS 2014, 7, 565-574.
Dimopoulos, I. ; Huan, T. ; Li, L. ; Sauve, Y. Application Of Stable Isotope-Assisted Metabolomics In Neovascular (Wet) Age-Related Macular Degeneration (Amd). INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 2014, 55.

2013

Li, L. ; Li, R. ; Zhou, J. ; Zuniga, A. ; Stanislaus, A. E. ; Wu, Y. ; Huan, T. ; Zheng, J. ; Shi, Y. ; Wishart, D. S. ; Lin, G. Mycompoundid: Using An Evidence-Based Metabolome Library For Metabolite Identification. ANALYTICAL CHEMISTRY 2013, 85, 3401-3408.