| Title | Total Synthesis of Cladoniamide G |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Loosley, BC, Andersen, RJ, Dake, GR |
| Journal | ORGANIC LETTERS |
| Volume | 15 |
| Pagination | 1152-1154 |
| Date Published | MAR 1 |
| ISSN | 1523-7060 |
| Abstract | The total synthesis of cladoniamide G, a cytotoxic compound against MCF-7 breast cancer cells (10 mu g/mL), was accomplished. Key steps in the sequence include oxidative dimerization of 3-acetoxy-5-chloroindole and a tandem process incorporating three steps: bimolecular carbonyl addition, lactam formation, and carbamate removal. |
| DOI | 10.1021/ol400055v |
