Title | Total synthesis of streptonigrone |
Publication Type | Journal Article |
Year of Publication | 2007 |
Authors | Chan, BK, Ciufolini, MA |
Journal | Journal of Organic Chemistry |
Volume | 72 |
Pagination | 8489-8495 |
Date Published | Oct |
ISBN Number | 0022-3263 |
Abstract | A total synthesis of streptonigrone, 1, is described, which incorporates a one-step synthesis of substituted pyridones devised in our laboratory. Other aspects of the synthesis that differentiate the present approach from previous ones are the use of a Conrad - Limpach reaction, rather than the customary Friedlander methodology, to assemble the quinoline segment of 1, and the implementation of an anionic sequence for the functionalization of a key pyridone intermediate. |
URL | <Go to ISI>://000250344300040 |
