Our Department

Faculty Directory Header Image
  1. Our Department
  2. History
  3. Gregory Dake

Gregory Dake

Profile

Featured Publications

He, Q. ; Cao, L. ; Wei, Y. ; Dake, G. R. Utility Of 2-Diphenylphosphoryloxy-1,3-Dienes In Multicomponent Hetero-Diels-Alder Reactions To Construct Functionalized Six-Membered Nitrogen Heterocycles. Chemistry: A European Journal 2022, 28, e202201328.
Voth, C. N. ; Dake, G. R. Nickel-Catalyzed Arylative Additions On 2-Alkynyl-N-Arylsulfonylanilides To Construct Functionalized Indoles. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2020, 2020, 744-748.
Knox, K. J. ; Gillis, E. A. L. ; Dake, G. R. A Positive Student Experience Of Collaborative Project Work In Upper-Year Undergraduate Chemistry. CHEMISTRY EDUCATION RESEARCH AND PRACTICE 2019, 20, 340-357.
Stewart, J. J. ; Dake, G. R. Activating Students' Prior Knowledge Using A Bridge Activity As An Initial Interactive Discussion In A Flipped Organic Chemistry Course. Journal of Chemical Education 2019, 96, 2426-2431.

Research and Teaching Interests

Research background: synthetic organic chemistry

Teaching background: I have taught CHEM_V 123, CHEM_V 203, CHEM_V 213, CHEM_V 233, CHEM_V 313, CHEM_V 3x5 (third year labs), CHEM_V 330, CHEM_V 411/566. I created and was the first instructor for CHEM_V 341. I co-created and was one of the original instructors for CHEM_V 460. I have taught CHEM_V 540 for organic graduate students, CHEM_V 568A (special topics graduate course on the use of inorganic catalysts and organometallic compounds in complex synthetic organic chemistry).  Awarded a Science Undergraduate Society Teaching Excellence award in 2010 and a UBC Killam Teaching Prize in 2012. He believes in the concept of deliberate practice in education. He was a UBC Sustainability Initiative Teaching and Learning Fellow in 2013.

...........

About Gregory Dake: Gregory Dake was a B.Sc. (Hons) student at UBC a long time ago. Ph.D. at Stanford University with Professor Barry Trost.  Postdoctoral work with Gilbert Stork at Columbia University (in the City of New York). Employment at UBC followed. Currently Undergraduate Advisor in the Department of Chemistry. When he commutes, he often listens to the following podcasts: 99% Invisible, You Must Remember This, Switched on Pop, Sticky Notes, Good One, The Rewatchables, Blank Check.

Contact

Real name: 
Gregory Dake
Email: 
Office Room Number(s): 
Chem D318
Office Phone Number: 
604-822-9121
Fax Number: 
604-822-2847

Curriculum Vitae

B.Sc.(Hons.), British Columbia (1992); Ph.D. Stanford University (Barry M. Trost, 1998); Postdoctoral, Columbia University (Gilbert Stork, 1998-1999).

2010 Science Undergraduate Society Teaching Excellence Award

2012 University of British Columbia Killam Teaching Prize

2013 University of B.C. Sustainability Teaching and Learning Fellow

2020 Faculty of Science Excellence in Service Award, March 2021

2016-2025 Associate Head, Undergraduate; Undergraduate Advisor

2021- President's Advisory Committee on Student Discipline

2025 - Chair, Faculty of Science Curriculum Committee

 

 

Publications

2022

He, Q. ; Cao, L. ; Wei, Y. ; Dake, G. R. Utility Of 2-Diphenylphosphoryloxy-1,3-Dienes In Multicomponent Hetero-Diels-Alder Reactions To Construct Functionalized Six-Membered Nitrogen Heterocycles. Chemistry: A European Journal 2022, 28, e202201328.

2020

Voth, C. N. ; Dake, G. R. Nickel-Catalyzed Arylative Additions On 2-Alkynyl-N-Arylsulfonylanilides To Construct Functionalized Indoles. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2020, 2020, 744-748.

2019

Knox, K. J. ; Gillis, E. A. L. ; Dake, G. R. A Positive Student Experience Of Collaborative Project Work In Upper-Year Undergraduate Chemistry. CHEMISTRY EDUCATION RESEARCH AND PRACTICE 2019, 20, 340-357.
Stewart, J. J. ; Dake, G. R. Activating Students' Prior Knowledge Using A Bridge Activity As An Initial Interactive Discussion In A Flipped Organic Chemistry Course. Journal of Chemical Education 2019, 96, 2426-2431.

2016

Serin, S. C. ; Dake, G. R. ; Gates, D. P. Phosphaalkene-Oxazoline Copolymers With Styrene As Chiral Ligands For Rhodium(I). Dalton Transactions 2016, 45, 5666.
Serin, S. C. ; Dake, G. R. ; Gates, D. P. Addition-Isomerization Polymerization Of Chiral Phosphaalkenes: Observation Of Styrene-Phosphaalkene Linkages In A Random Copolymer. Macromolecules 2016, 49, 4075.
Serin, S. C. ; Dake, G. R. ; Gates, D. P. Copper(I) Complexes Of Pyridine-Bridged Phosphaalkene-Oxazoline Pincer Ligands. Inorganic Chemistry 2016, 55, 6678.

2014

Castillo-Contreras, E. B. ; Stahl, A. M. ; Dake, G. R. Annulated Isoxazoles Via [3+2] Cycloaddition Of Alkenyl Bromides And Oximoyl Chlorides And Ag(I) Promoted Elimination. JOURNAL OF ORGANIC CHEMISTRY 2014, 79, 7250-7255.
Castillo-Contreras, E. B. ; Dake, G. R. Dmap Promoted Tandem Addition Reactions Forming Substituted Tetrahydroxanthones. ORGANIC LETTERS 2014, 16, 1642-1645.
Serin, S. C. ; Patrick, B. O. ; Dake, G. R. ; Gates, D. P. Reaction Of An Enantiomerically Pure Phosphaalkene-Oxazoline With Mem Nucleophiles (M = Li And Mgbr): Stereoselectivity And Noninnocence Of The P-Mesityl Substituent. ORGANOMETALLICS 2014, 33, 7215-7222.

2013

Vilin, Y. Y. ; Nunez, J. - J. ; Kim, R. Y. ; Dake, G. R. ; Kurata, H. T. Paradoxical Activation Of An Inwardly Rectifying Potassium Channel Mutant By Spermine: ``(B)Locking'' Open The Bundle Crossing Gate. MOLECULAR PHARMACOLOGY 2013, 84, 572-581.
Sala-Rabanal, M. ; Li, D. C. ; Dake, G. R. ; Kurata, H. T. ; Inyushin, M. ; Skatchkov, S. N. ; Nichols, C. G. Polyamine Transport By The Polyspecific Organic Cation Transporters Oct1, Oct2, And Oct3. MOLECULAR PHARMACEUTICS 2013, 10, 1450-1458.
Loosley, B. C. ; Andersen, R. J. ; Dake, G. R. Total Synthesis Of Cladoniamide G. ORGANIC LETTERS 2013, 15, 1152-1154.

2012

Dugal-Tessier, J. ; Serin, S. C. ; Castillo-Contreras, E. B. ; Conrad, E. D. ; Dake, G. R. ; Gates, D. P. Enantiomerically Pure Phosphaalkene-Oxazolines (Phak-Ox): Synthesis, Scope And Copolymerization With Styrene. CHEMISTRY-A EUROPEAN JOURNAL 2012, 18, 6349-6359.
Dake, G. R. Enamides And Related Functional Groups As Nucleophilic Components In Ring-Forming Processes Catalyzed By Electrophilic Metal Salts. SYNLETT 2012, 814-824.

2010

Dugal-Tessier, J. ; Dake, G. R. ; Gates, D. P. Chiral Phosphaalkene-Oxazoline Ligands For The Palladium-Catalyzed Asymmetric Allylic Alkylation. Organic Letters 2010, 12, 4667 - 4669.
Kozak, J. A. ; Patrick, B. O. ; Dake, G. R. Gold(I)-Catalyzed Intramolecular Tandem Addition/friedel-Crafts Reactions Between Acyclic Enamides And 1-Arylalkynes. Journal of Organic Chemistry 2010, 75, 8585 - 8590.
Dugal-Tessier, J. ; Kuhn, P. - S. ; Dake, G. R. ; Gates, D. P. Synthesis Of Functional Phosphines With Ortho-Substituted Aryl Groups: 2-Rc6H4Ph2 And 2-Rc6H4P(Sime3)2 (R = 2-I-Pr- Or 2-T-Bu-). Heteroatom Chemistry 2010, 21, 265 - 270.
Dugal-Tessier, J. ; Kuhn, P. - S. ; Dake, G. R. ; Gates, D. P. Synthesis Of Functional Phosphines With Ortho-Substituted Aryl Groups: 2-Rc6H4Ph2 And 2-Rc6H4P(Sime3)2 (R = 2-I-Pr- Or 2-T-Bu-). [Erratum To Document Cited In Ca153:260428]. Heteroatom Chemistry 2010, 21, 355 - 360.

2009

Kozak, J. A. ; Dodd, J. M. ; Harrison, T. J. ; Jardine, K. J. ; Patrick, B. O. ; Dake, G. R. Enamides And Enesulfonamides As Nucleophiles: Formation Of Complex Ring Systems Through A Platinum(Ii)-Catalyzed Addition/friedel-Crafts Pathway. Journal of Organic Chemistry 2009, 74, 6929-6935.

2008

Dake, G. R. ; Fenster, E. E. ; Patrick, B. O. A Synthetic Approach To The Fusicoccane A-B Ring Fragment Based On A Pauson-Khand Cycloaddition/norrish Type 1 Fragmentation. Journal of Organic Chemistry 2008, 73, 6711-6715.
Hurley, P. B. ; Dake, G. R. Synthetic Studies Toward Halichlorine: Complex Azaspirocycle Formation With Use Of An Nbs-Promoted Semipinacol Reaction. Journal of Organic Chemistry 2008, 73, 4131-4138.
Dugal-Tessier, J. ; Dake, G. R. ; Gates, D. P. Chiral Ligand Design: A Bidentate Ligand Incorporating An Acyclic Phosphaalkene. Angewandte Chemie-International Edition 2008, 47, 8064-8067.
Kozak, J. A. ; Dake, G. R. Total Synthesis Of (+)-Fawcettidine. Angewandte Chemie-International Edition 2008, 47, 4221-4223.

2007

Harrison, T. J. ; Patrick, B. O. ; Dake, G. R. Platinum(Ii)-Catalyzed Cyclizations Forming Quaternary Carbon Centers, Using Enesulfonamides, Enecarbamates, Or Enamides As Nucleophiles. Organic Letters 2007, 9, 367-370.
Dugal-Tessier, J. ; Dake, G. R. ; Gates, D. P. P,n-Chelate Complexes Of Pd(Ii) And Pt(Ii) Based On A Phosphaalkene Motif: A Catalyst For The Overman-Claisen Rearrangement. Organometallics 2007, 26, 6481-6486.

2006

Wilson, M. S. ; Woo, J. C. S. ; Dake, G. R. A Synthetic Approach Toward Nitiol: Construction Of Two 1,22-Dihydroxynitianes. Journal of Organic Chemistry 2006, 71, 4237-4245.
Harrison, T. J. ; Kozak, J. A. ; Corbella-Pane, M. ; Dake, G. R. Pyrrole Synthesis Catalyzed By Agotf Or Cationic Au(I) Complexes. Journal of Organic Chemistry 2006, 71, 4525-4529.
Dake, G. R. Recent Approaches To The Construction Of 1-Azaspiro[4.5]Decanes And Related 1-Azaspirocycles. Tetrahedron 2006, 62, 3467-3492.

2005

Harrison, T. J. ; Dake, G. R. Expeditious, High-Yielding Construction Of The Food Aroma Compounds 6-Acetyl-1,2,3,4-Tetrahydropyridine And 2-Acetyl-1-Pyrroline. Journal of Organic Chemistry 2005, 70, 10872-10874.
Fenster, M. D. B. ; Dake, G. R. An Asymmetric Formal Synthesis Of Fasicularin. Chemistry-a European Journal 2005, 11, 639-649.

2004

Easton, L. P. ; Dake, G. R. Nucleophilic Additions Of Lactam-Derived Enol Triflates To Aldehydes Mediated By Nickel(Ii) And Chromium(Ii) Salts. Canadian Journal of Chemistry-Revue Canadienne De Chimie 2004, 82, 139-144.
Woo, J. C. S. ; Fenster, E. ; Dake, G. R. A Convenient Method For The Conversion Of Hindered Carboxylic Acids To N-Methoxy-N-Methyl (Weinreb) Amides. Journal of Organic Chemistry 2004, 69, 8984-8986.
Harrison, T. J. ; Dake, G. R. Pt(Ii) Or Ag(I) Salt Catalyzed Cycloisomerizations And Tandem Cycloadditions Forming Functionalized Azacyclic Arrays. Organic Letters 2004, 6, 5023-5026.
Dake, G. R. ; Fenster, M. D. B. ; Fleury, M. ; Patrick, B. O. Investigations Of Alpha-Siloxy-Epoxide Ring Expansions Forming 1-Azaspirocyclic Ketones. Journal of Organic Chemistry 2004, 69, 5676-5683.
Dake, G. R. ; Fenster, M. D. B. ; Hurley, P. B. ; Patrick, B. O. Synthesis Of Functionalized 1-Azaspirocyclic Cyclopentanones Using Bronsted Acid Or N-Bromosuccinimide Promoted Ring Expansions. Journal of Organic Chemistry 2004, 69, 5668-5675.

2003

Fenster, M. D. B. ; Dake, G. R. A Formal Construction Of Fasicularin. Organic Letters 2003, 5, 4313-4316.
Hurley, P. B. ; Dake, G. R. N-Bromosuccinimide Promoted Ring Expansion Reactions: Diastereoselective Formation Of Functionalized Azaspirocyclic Cyclopentanones. Synlett 2003, 2131-2134.

2001

Fenster, M. D. B. ; Patrick, B. O. ; Dake, G. R. Construction Of Azaspirocyclic Ketones Through Alpha-Hydroxyiminium Ion Or Alpha-Siloxy Epoxide Semipinacol Rearrangements. Organic Letters 2001, 3, 2109-2112.
Wilson, M. S. ; Dake, G. R. Stereocontrolled Construction Of The A-Ring Of Nitiol Using A Pauson-Khand Cycloaddition-Ring Fragmentation Strategy. Organic Letters 2001, 3, 2041-2044.