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Harry Brumer

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Featured Publications

Larsbrink, J. ; Rogers, T. E. ; Hemsworth, G. R. ; McKee, L. S. ; Tauzin, A. S. ; Spadiut, O. ; Klinter, S. ; Pudlo, N. A. ; Urs, K. ; Koropatkin, N. M. ; A. Creagh, L. ; Haynes, C. A. ; Kelly, A. G. ; Cederholm, S. Nilsson; Davies, G. J. ; Martens, E. C. ; Brumer, H. A Discrete Genetic Locus Confers Xyloglucan Metabolism In Select Human Gut Bacteroidetes. Nature 2014, 506, 498–502.
Eklof, J. M. ; Shojania, S. ; Okon, M. ; McIntosh, L. P. ; Brumer, H. Structure-Function Analysis Of A Broad Specificity Populus Trichocarpa Endo-Beta-Glucanase Reveals An Evolutionary Link Between Bacterial Licheninases And Plant Xth Gene Products. Journal of Biological Chemistry 2013, 288, 15786-15799.
Xu, C. ; Spadiut, O. ; Araujo, A. Catarina; Nakhai, A. ; Brumer, H. Chemo-Enzymatic Assembly Of Clickable Cellulose Surfaces Via Multivalent Polysaccharides. ChemSusChem 2012, 5, 661-665.
Araujo, A. Catarina; Song, Y. ; Lundeberg, J. ; Stahl, P. L. ; Brumer, H. Activated Paper Surfaces For The Rapid Hybridization Of Dna Through Capillary Transport. Analytical Chemistry 2012, 84, 3311-3317.
Ibatullin, F. M. ; Banasiak, A. ; Baumann, M. J. ; Greffe, L. ; Takahashi, J. ; Mellerowicz, E. J. ; Brumer, H. A Real-Time Fluorogenic Assay For The Visualization Of Glycoside Hydrolase Activity In Planta. Plant Physiology 2009, 151, 1741-1750.

Research and Teaching Interests

Research in my group is focused on structure-function studies and applications of carbohydrate-active enzymes.  Please see my page at the Michael Smith Laboratories for more information: http://www.msl.ubc.ca/faculty/brumer

Contact

Real name: 
Harry Brumer
Email: 
Office Room Number(s): 
325 Michael Smith Laboratories
Office Phone Number: 
604-827-3738
Lab Room: 
263 Michael Smith Laboratories
Lab Phone: 
604-827-3759

Curriculum Vitae

  • B.Sc., Michigan State University, East Lansing, USA (1993)
  • M.Sc., University of Illinois at Chicago, USA (R.M. Moriarty, 1995)
  • Ph.D., University of Manchester Institute of Science and Technology (UMIST), UK (M.L. Sinnott, 1998)
  • Post-doctoral, University of British Columbia, Canada (S.G. Withers, 1998-1999)
  • Assistant Professor, Royal Institute of Technology (KTH), Sweden (1999-2004)
  • Associate Professor,  Royal Institute of Technology (KTH), Sweden (2004-2011)
  • Full Professor,  Royal Institute of Technology (KTH), Sweden (Jan. 2011)
  • Full Professor, Michael Smith Laboratories and Department of Chemistry, University of British Columbia, Canada (Sept. 2011)

Publications

2015

Fenger, T. Hauch; Brumer, H. Synthesis And Analysis Of Specific Covalent Inhibitors Of Endo-Xyloglucanases. CHEMBIOCHEM 2015, 16, 575-583.

2014

Leppanen, A. - S. ; Xu, C. ; Parikka, K. ; Eklund, P. ; Sjoholm, R. ; Brumer, H. ; Tenkanen, M. ; Willfor, S. Targeted Allylation And Propargylation Of Galactose-Containing Polysaccharides In Water. CARBOHYDRATE POLYMERS 2014, 100, 46-54.
Wang, Y. ; Vilaplana, F. ; Brumer, H. ; Aspeborg, H. Enzymatic Characterization Of A Glycoside Hydrolase Family 5 Subfamily 7 (Gh5\_7) Mannanase From Arabidopsis Thaliana. Planta 2014, 239, 653–665.
Banasiak, A. ; Ibatullin, F. M. ; Brumer, H. ; Mellerowicz, E. J. Glycoside Hydrolase Activities In Cell Walls Of Sclerenchyma Cells In The Inflorescence Stems Of Arabidopsis Thaliana Visualized In Situ. Plants 2014, 3, 513–525.
Song, Y. ; Gyarmati, P. ; Araujo, A. Catarina; Lundeberg, J. ; Brumer, H. ; Staahl, P. L. Visual Detection Of Dna On Paper Chips. Analytical chemistry 2014, 86, 1575–1582.
Larsbrink, J. ; Rogers, T. E. ; Hemsworth, G. R. ; McKee, L. S. ; Tauzin, A. S. ; Spadiut, O. ; Klinter, S. ; Pudlo, N. A. ; Urs, K. ; Koropatkin, N. M. ; A. Creagh, L. ; Haynes, C. A. ; Kelly, A. G. ; Cederholm, S. Nilsson; Davies, G. J. ; Martens, E. C. ; Brumer, H. A Discrete Genetic Locus Confers Xyloglucan Metabolism In Select Human Gut Bacteroidetes. Nature 2014, 506, 498–502.
Oksanen, A. ; Retulainen, E. ; Brumer, H. Bulky Paper With Good Strength And Smoothness? Certainly!. NORDIC PULP & PAPER RESEARCH JOURNAL 2014, 29, 725-731.
Martens, E. C. ; Kelly, A. G. ; Tauzin, A. S. ; Brumer, H. The Devil Lies In The Details: How Variations In Polysaccharide Fine-Structure Impact The Physiology And Evolution Of Gut Microbes. JOURNAL OF MOLECULAR BIOLOGY 2014, 426, 3851-3865.
Brumer, H. ; Gilbert, H. J. Editorial Overview: Carbohydrate-Protein Interactions: The Future Is Taking Shape. CURRENT OPINION IN STRUCTURAL BIOLOGY 2014, 28, V-VII.
Larsbrink, J. ; Thompson, A. J. ; Lundqvist, M. ; Gardner, J. G. ; Davies, G. J. ; Brumer, H. A Complex Gene Locus Enables Xyloglucan Utilization In The Model Saprophyte Cellvibrio Japonicus. MOLECULAR MICROBIOLOGY 2014, 94, 418-433.
Anasontzis, G. E. ; Pena, M. Salazar; Spadiut, O. ; Brumer, H. ; Olsson, L. Effects Of Temperature And Glycerol And Methanol-Feeding Profiles On The Production Of Recombinant Galactose Oxidase In Pichia Pastoris. BIOTECHNOLOGY PROGRESS 2014, 30, 728-735.
Song, Y. ; Gyarmati, P. ; Araujo, A. Catarina; Lundeberg, J. ; , ; Stahl, P. L. Visual Detection Of Dna On Paper Chips. ANALYTICAL CHEMISTRY 2014, 86, 1575-1582.

2013

Araujo, A. Catarina; Song, Y. ; Lundeberg, J. ; Stahl, P. L. ; Brumer, H. Activated Paper Surfaces For The Rapid Hybridization Of Dna Through Capillary Transport (Vol 84, Pg 3311, 2012). ANALYTICAL CHEMISTRY 2013, 85, 11676.
Eklof, J. M. ; Shojania, S. ; Okon, M. ; McIntosh, L. P. ; Brumer, H. Structure-Function Analysis Of A Broad Specificity Populus Trichocarpa Endo-Beta-Glucanase Reveals An Evolutionary Link Between Bacterial Licheninases And Plant Xth Gene Products. Journal of Biological Chemistry 2013, 288, 15786-15799.
Thongpoo, P. ; McKee, L. S. ; Araujo, A. Catarina; Kongsaeree, P. T. ; Brumer, H. Identification Of The Acid/base Catalyst Of A Glycoside Hydrolase Family 3 (Gh3) Beta-Glucosidase From Aspergillus Niger Asku28. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 2013, 1830, 2739-2749.
Stepper, J. ; Dabin, J. ; Eklof, J. M. ; Thongpoo, P. ; Kongsaeree, P. ; Taylor, E. J. ; Turkenburg, J. P. ; Brumer, H. ; Davies, G. J. Structure And Activity Of The Streptococcus Pyogenes Family Gh1 6-Phospho-Beta-Glucosidase Spy1599. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 2013, 69, 16-23.
Kaewthai, N. ; Gendre, D. ; Eklof, J. M. ; Ibatullin, F. M. ; Ezcurra, I. ; Bhalerao, R. P. ; Brumer, H. Group Iii-A Xth Genes Of Arabidopsis Encode Predominant Xyloglucan Endohydrolases That Are Dispensable For Normal Growth. PLANT PHYSIOLOGY 2013, 161, 440-454.

2012

Larsbrink, J. ; Izumi, A. ; Hemsworth, G. R. ; Davies, G. J. ; Brumer, H. Structural Enzymology Of Cellvibrio Japonicus Agd31B Protein Reveals Alpha-Transglucosylase Activity In Glycoside Hydrolase Family 31. JOURNAL OF BIOLOGICAL CHEMISTRY 2012, 287, 43288-43299.
Silipo, A. ; Larsbrink, J. ; Marchetti, R. ; Lanzetta, R. ; Brumer, H. ; Molinaro, A. Nmr Spectroscopic Analysis Reveals Extensive Binding Interactions Of Complex Xyloglucan Oligosaccharides With The Cellvibrio Japonicus Glycoside Hydrolase Family 31 A-Xylosidase. CHEMISTRY-A EUROPEAN JOURNAL 2012, 18, 13395-13404.
Aspeborg, H. ; Coutinho, P. M. ; Wang, Y. ; Brumer, H. ; Henrissat, B. Evolution, Substrate Specificity And Subfamily Classification Of Glycoside Hydrolase Family 5 (Gh5). BMC EVOLUTIONARY BIOLOGY 2012, 12, 186.
Parikka, K. ; Leppanen, A. - S. ; Xu, C. ; Pitkanen, L. ; Eronen, P. ; Osterberg, M. ; Brumer, H. ; Willfor, S. ; Tenkanen, M. Functional And Anionic Cellulose-Interacting Polymers By Selective Chemo-Enzymatic Carboxylation Of Galactose-Containing Polysaccharides. BIOMACROMOLECULES 2012, 13, 2418-2428.
Araujo, A. Catarina; Nakhai, A. ; Ruda, M. ; Slattegard, R. ; Gatenholm, P. ; Brumer, H. A General Route To Xyloglucan-Peptide Conjugates For The Activation Of Cellulose Surfaces. CARBOHYDRATE RESEARCH 2012, 354, 116-120.
Araujo, A. Catarina; Song, Y. ; Lundeberg, J. ; Stahl, P. L. ; Brumer, H. Activated Paper Surfaces For The Rapid Hybridization Of Dna Through Capillary Transport. Analytical Chemistry 2012, 84, 3311-3317.
Bi, R. ; Spadiut, O. ; Lawoko, M. ; Brumer, H. ; Henriksson, G. Isolation And Identification Of Microorganisms From Soil Able To Live On Lignin As A Carbon Source And To Produce Enzymes Which Cleave The Beta-O-4 Bond In A Lignin Model Compound. CELLULOSE CHEMISTRY AND TECHNOLOGY 2012, 46, 227-242.
Eklof, J. M. ; Ruda, M. C. ; Brumer, H. Distinguishing Xyloglucanase Activity In Endo-Beta(1 -> 4)Glucanases. In CELLULASES; Gilbert, H. J. ; CELLULASES; 2012; Vol. 510, pp. 97-120.
Xu, C. ; Spadiut, O. ; Araujo, A. Catarina; Nakhai, A. ; Brumer, H. Chemo-Enzymatic Assembly Of Clickable Cellulose Surfaces Via Multivalent Polysaccharides. ChemSusChem 2012, 5, 661-665.

2011

Zhang, Q. ; Brumer, H. ; Ågren, H. ; Tu, Y. The Adsorption Of Xyloglucan On Cellulose: Effects Of Explicit Water And Side Chain Variation. Carbohydrate Research 2011, 346, 2595 - 2602.
Spadiut, O. ; Ibatullin, F. M. ; Peart, J. ; Gullfot, F. ; Martinez-Fleites, C. ; Ruda, M. ; Xu, C. ; Sundqvist, G. ; Davies, G. J. ; Brumer, H. Building Custom Polysaccharides In Vitro With An Efficient, Broad-Specificity Xyloglucan Glycosynthase And A Fucosyltransferase. Journal of the American Chemical Society 2011, 133, 10892 - 10900.
Larsbrink, J. ; Izumi, A. ; Ibatullin, F. M. ; Nakhai, A. ; Gilbert, H. J. ; Davies, G. J. ; Brumer, H. Structural And Enzymatic Characterization Of A Glycoside Hydrolase Family 31 Α-Xylosidase From Cellvibrio Japonicus Involved In Xyloglucan Saccharification. Biochemical Journal 2011, 436, 567 - 580.
Cartmell, A. ; McKee, L. S. ; Pena, M. J. ; Larsbrink, J. ; Brumer, H. ; Kaneko, S. ; Ichinose, H. ; Lewis, R. J. ; Vikso-Nielsen, A. ; Gilbert, H. J. ; Marles-Wright, J. The Structure And Function Of An Arabinan-Specific Alpha-1,2-Arabinofuranosidase Identified From Screening The Activities Of Bacterial Gh43 Glycoside Hydrolases. Journal of Biological Chemistry 2011, 286, 15483-15495.
Maris, A. ; Kaewthai, N. ; Eklof, J. M. ; Miller, J. G. ; Brumer, H. ; Fry, S. C. ; Verbelen, J. - P. ; Vissenberg, K. Differences In Enzymic Properties Of Five Recombinant Xyloglucan Endotransglucosylase/hydrolase (Xth) Proteins Of Arabidopsis Thaliana. Journal of Experimental Botany 2011, 62, 261 - 271.
Nishikubo, N. ; Takahashi, J. ; Roos, A. A. ; Derba-Maceluch, M. ; Piens, K. ; Brumer, H. ; Teeri, T. T. ; Stalbrand, H. ; Mellerowicz, E. J. Xyloglucan Endo-Transglycosylase-Mediated Xyloglucan Rearrangements In Developing Wood Of Hybrid Aspen. PLANT PHYSIOLOGY 2011, 155, 399 - 413.
Fink, H. ; Ahrenstedt, L. ; Bodin, A. ; Brumer, H. ; Gatenholm, P. ; Krettek, A. ; Risberg, B. Bacterial Cellulose Modified With Xyloglucan Bearing The Adhesion Peptide Rgd Promotes Endothelial Cell Adhesion And Metabolism - A Promising Modification For Vascular Grafts. Journal of Tissue Engineering and Regenerative Medicine 2011, 5, 454-463.
Oksanen, A. ; Timo, R. ; Retulainen, E. ; Salminen, K. ; Brumer, H. Improving Wet Web Runnability And Paper Quality By An Uncharged Polysaccharide. Journal of Biobased Materials and Bioenergy 2011, 5, 187-191.
Mark, P. ; Zhang, Q. ; Czjzek, M. ; Brumer, H. ; Agren, H. Molecular Dynamics Simulations Of A Branched Tetradecasaccharide Substrate In The Active Site Of A Xyloglucan Endo-Transglycosylase. Molecular Simulation 2011, 37, 1001-1013.
Nishikubo, N. ; Takahashi, J. ; Roos, A. A. ; Derba-Maceluch, M. ; Piens, K. ; Brumer, H. ; Teeri, T. T. ; Stalbrand, H. ; Mellerowicz, E. J. Xyloglucan Endo-Transglycosylase-Mediated Xyloglucan Rearrangements In Developing Wood Of Hybrid Aspen. Plant Physiology 2011, 155, 399-413.
Ariza, A. ; Eklof, J. M. ; Spadiut, O. ; Offen, W. A. ; Roberts, S. M. ; Besenmatter, W. ; Friis, E. P. ; Skjot, M. ; Wilson, K. S. ; Brumer, H. ; Davies, G. Structure And Activity Of Paenibacillus Polymyxa Xyloglucanase From Glycoside Hydrolase Family 44. Journal of Biological Chemistry 2011, 286, 33890-33900.

2010

Fink, H. ; Ahrenstedt, L. ; Bodin, A. ; Brumer, H. ; Gatenholm, P. ; Krettek, A. ; Risberg, B. Bacterial Cellulose Modified With Xyloglucan Bearing The Adhesion Peptide Rgd Promotes Endothelial Cell Adhesion And Metabolism-A Promising Modification For Vascular Grafts. Journal of Tissue Engineering and Regenerative Medicine 2010, 5, 454 - 463.
Oksanen, A. ; Timo, R. ; Retulainen, E. ; Salminen, K. ; Brumer, H. Improving Wet Web Runnability And Paper Quality By An Uncharged Polysaccharide. In RESEARCH PROGRESS IN PAPER INDUSTRY AND BIOREFINERY (4TH ISETPP), VOLS 1-3; Sun, R. C. ; Fu, S. Y. ; RESEARCH PROGRESS IN PAPER INDUSTRY AND BIOREFINERY (4TH ISETPP), VOLS 1-3; 2010; pp. 1444-1447.
Guce, A. I. ; Clark, N. E. ; Salgado, E. N. ; Ivanen, D. R. ; Kulminskaya, A. A. ; Brumer, H. ; Garman, S. C. Catalytic Mechanism Of Human Alpha-Galactosidase. Journal of Biological Chemistry 2010, 285, 3625-3632.
Gullfot, F. ; Tan, T. C. ; von Schantz, L. ; Karlsson, E. N. ; Ohlin, M. ; Brumer, H. ; Divne, C. The Crystal Structure Of Xg-34, An Evolved Xyloglucan-Specific Carbohydrate-Binding Module. Proteins-Structure Function and Bioinformatics 2010, 78, 785-789.
Kaewthai, N. ; Harvey, A. J. ; Hrmova, M. ; Brumer, H. ; Ezcurra, I. ; Teeri, T. T. ; Fincher, G. B. Heterologous Expression Of Diverse Barley Xth Genes In The Yeast Pichia Pastoris. Plant Biotechnology 2010, 27, 251-258.
Lombard, V. ; Bernard, T. ; Rancurel, C. ; Brumer, H. ; Coutinho, P. M. ; Henrissat, B. A Hierarchical Classification Of Polysaccharide Lyases For Glycogenomics. Biochemical Journal 2010, 432, 437-444.
Eklof, J. M. ; Brumer, H. The Xth Gene Family: An Update On Enzyme Structure, Function, And Phylogeny In Xyloglucan Remodeling. Plant Physiology 2010, 153, 456-466.
Oksanen, A. ; Timo, R. ; Retulainen, E. ; Salminen, K. ; Brumer, H. Improving Wet Web Runnability And Paper Quality By An Uncharged Polysaccharide; 2010; pp. 1444-1447.
Brumer, H. Carbohydrases. In The Encyclopedia of Catalysis; Horváth, I. T. ; The Encyclopedia of Catalysis; John Wiley and Sons: New York, 2010.
Spadiut, O. ; Olsson, L. ; Brumer, H. A Comparative Summary Of Expression Systems For The Recombinant Production Of Galactose Oxidase. MICROBIAL CELL FACTORIES 2010, 9, 68.

2009

von Schantz, L. ; Gullfot, F. ; Scheer, S. ; Filonova, L. ; Gunnarsson, L. Cicortas; Flint, J. E. ; Daniel, G. ; Nordberg-Karlsson, E. ; Brumer, H. ; Ohlin, M. Affinity Maturation Generates Greatly Improved Xyloglucan-Specific Carbohydrate Binding Modules. BMC BIOTECHNOLOGY 2009, 9, 92.
Zhou, Q. ; Brumer, H. ; Teeri, T. T. Self-Organization Of Cellulose Nanocrystals Adsorbed With Xyloglucan Oligosaccharide-Poly(Ethylene Glycol)-Polystyrene Triblock Copolymer. MACROMOLECULES 2009, 42, 5430-5432.
Takahashi, J. ; Rudsander, U. J. ; Hedenstrom, M. ; Banasiak, A. ; Harholt, J. ; Amelot, N. ; Immerzeel, P. ; Ryden, P. ; Endo, S. ; Ibatullin, F. M. ; Brumer, H. ; del Campillo, E. ; Master, E. R. ; Scheller, H. Vibe; Sundberg, B. ; Teeri, T. T. ; Mellerowicz, E. J. Korrigan1 And Its Aspen Homolog Pttcel9A1 Decrease Cellulose Crystallinity In Arabidopsis Stems. PLANT AND CELL PHYSIOLOGY 2009, 50, 1099-1115.
Mark, P. ; Baumann, M. J. ; Eklof, J. M. ; Gullfot, F. ; Michel, G. ; Kallas, A. M. ; Teeri, T. T. ; Brumer, H. ; Czjzek, M. Analysis Of Nasturtium Tmnxg1 Complexes By Crystallography And Molecular Dynamics Provides Detailed Insight Into Substrate Recognition By Family Gh16 Xyloglucan Endo-Transglycosylases And Endo-Hydrolases. Proteins-Structure Function and Bioinformatics 2009, 75, 820-836.
Eklof, J. M. ; Tan, T. C. ; Divne, C. ; Brumer, H. The Crystal Structure Of The Outer Membrane Lipoprotein Ybhc From Escherichia Coli Sheds New Light On The Phylogeny Of Carbohydrate Esterase Family 8. Proteins-Structure Function and Bioinformatics 2009, 76, 1029-1036.
Gullfot, F. ; Ibatullin, F. M. ; Sundqvist, G. ; Davies, G. J. ; Brumer, H. Functional Characterization Of Xyloglucan Glycosynthases From Gh7, Gh12, And Gh16 Scaffolds. Biomacromolecules 2009, 10, 1782-1788.
Ibatullin, F. M. ; Banasiak, A. ; Baumann, M. J. ; Greffe, L. ; Takahashi, J. ; Mellerowicz, E. J. ; Brumer, H. A Real-Time Fluorogenic Assay For The Visualization Of Glycoside Hydrolase Activity In Planta. Plant Physiology 2009, 151, 1741-1750.
Eneyskaya, E. V. ; Sundqvist, G. ; Golubev, A. M. ; Ibatullin, F. M. ; Ivanen, D. R. ; Shabalin, K. A. ; Brumer, H. ; Kulminskaya, A. A. Transglycosylating And Hydrolytic Activities Of The Beta-Mannosidase From Trichoderma Reesei. Biochimie 2009, 91, 632-638.

2008

Piens, K. ; Faure, R. ; Sundqvist, G. ; Baumann, M. J. ; Saura-Valls, M. ; Teeri, T. T. ; Cottaz, S. ; Planas, A. ; Driguez, H. ; Brumer, H. Mechanism-Based Labeling Defines The Free Energy Change For Formation Of The Covalent Glycosyl-Enzyme Intermediate In A Xyloglucan Endo-Transglycosylase. JOURNAL OF BIOLOGICAL CHEMISTRY 2008, 283, 21864-21872.
Nordgren, N. ; Eklof, J. ; Zhou, Q. ; Brumer, H. ; Rutland, M. W. Top-Down Grafting Of Xyloglucan To Gold Monitored By Qcm-D And Afm: Enzymatic Activity And Interactions With Cellulose. BIOMACROMOLECULES 2008, 9, 942-948.
Ahrenstedt, L. ; Olksanen, A. ; Salminen, K. ; Brumer, H. Paper Dry Strength Improvement By Xyloglucan Addition: Wet-End Application, Spray Coating And Synergism With Borate. HOLZFORSCHUNG 2008, 62, 8-14.
Saura-Valls, M. ; Faure, R. ; Brumer, H. ; Teeri, T. T. ; Cottaz, S. ; Driguez, H. ; Planas, A. Active-Site Mapping Of A Populus Xyloglucan Endo-Transglycosylase With A Library Of Xylogluco-Oligosaccharides. Journal of Biological Chemistry 2008, 283, 21853-21863.
Rudsander, U. J. ; Sandstrom, C. ; Piens, K. ; Master, E. R. ; Wilson, D. B. ; Brumer, H. ; Kenne, L. ; Teeri, T. T. Comparative Nmr Analysis Of Cellooligosaccharide Hydrolysis By Gh9 Bacterial And Plant Endo-1,4-Beta-Glucanases. Biochemistry 2008, 47, 5235-5241.
Gilbert, H. J. ; Stalbrand, H. ; Brumer, H. How The Walls Come Crumbling Down: Recent Structural Biochemistry Of Plant Polysaccharide Degradation. Current Opinion in Plant Biology 2008, 11, 338-348.
Ibatullin, F. M. ; Baumann, M. J. ; Greffe, L. ; Brumer, H. Kinetic Analyses Of Retaining Endo-(Xylo)Glucanases From Plant And Microbial Sources Using New Chromogenic Xylogluco-Oligosaccharide Aryl Glycosides. Biochemistry 2008, 47, 7762-7769.

2007

Bodin, A. ; Ahrenstedt, L. ; Fink, H. ; Brumer, H. ; Risberg, B. ; Gatenholm, P. Modification Of Nanocellulose With A Xyloglucan-Rgd Conjugate Enhances Adhesion And Proliferation Of Endothelial Cells: Implications For Tissue Engineering. BIOMACROMOLECULES 2007, 8, 3697-3704.
Zhou, Q. ; Rutland, M. W. ; Teeri, T. T. ; Brumer, H. Xyloglucan In Cellulose Modification. CELLULOSE 2007, 14, 625-641.
Teeri, T. T. ; Brumer, H. ; Daniel, G. ; Gatenholm, P. Biomimetic Engineering Of Cellulose-Based Materials. TRENDS IN BIOTECHNOLOGY 2007, 25, 299-306.
Gloster, T. M. ; Ibatullin, F. M. ; Macauley, K. ; Eklof, J. M. ; Roberts, S. ; Turkenburg, J. P. ; Bjornvad, M. E. ; Jorgensen, P. Lina; Danielsen, S. ; Johansen, K. S. ; Borchert, T. V. ; Wilson, K. S. ; Brumer, H. ; Davies, G. J. Characterization And Three-Dimensional Structures Of Two Distinct Bacterial Xyloglucanases From Families Gh5 And Gh12. JOURNAL OF BIOLOGICAL CHEMISTRY 2007, 282, 19177-19189.
Sundqvist, G. ; Stenvall, M. ; Berglund, H. ; Ottosson, J. ; Brumer, H. A General, Robust Method For The Quality Control Of Intact Proteins Using Lc-Esi-Ms. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 2007, 852, 188-194.
Nishikubo, N. ; Awano, T. ; Banasiak, A. ; Bourquin, V. ; Ibatullin, F. ; Funada, R. ; Brumer, H. ; Teeri, T. T. ; Hayashi, T. ; Sundberg, B. ; Mellerowicz, E. J. Xyloglucan Endo-Transglycosylase (Xet) Functions In Gelatinous Layers Of Tension Wood Fibers In Poplar - A Glimpse Into The Mechanism Of The Balancing Act Of Trees. PLANT AND CELL PHYSIOLOGY 2007, 48, 843-855.
Baumann, M. J. ; Eklof, J. M. ; Michel, G. ; Kallas, A. M. ; Teeri, T. T. ; Czjzek, M. ; Brumer, H. Structural Evidence For The Evolution Of Xyloglucanase Activity From Xyloglucan Endo-Transglycosylases: Biological Implications For Cell Wall Metabolism. PLANT CELL 2007, 19, 1947-1963.
Comfort, D. A. ; Bobrov, K. S. ; Ivanen, D. R. ; Shabalin, K. A. ; Harris, J. M. ; Kulminskaya, A. A. ; Brumer, H. ; Kelly, R. M. Biochemical Analysis Of Thermotoga Maritima Gh36 Alpha-Galactosidase (Tmgala) Confirms The Mechanistic Commonality Of Clan Gh-D Glycoside Hydrolases. BIOCHEMISTRY 2007, 46, 3319-3330.
Piens, K. ; Henriksson, A. - M. ; Gullfot, F. ; Lopez, M. ; Faure, E. ; Ibatullin, F. M. ; Teeri, T. T. ; Driguez, H. ; Brumer, H. Glycosynthase Activity Of Hybrid Aspen Xyloglucan Endo-Transglycosylase Pttxet16-34 Nucleophile Mutants. ORGANIC & BIOMOLECULAR CHEMISTRY 2007, 5, 3971-3978.

2006

Gunnarsson, L. Cicortas; Zhou, Q. ; Montanier, C. ; Karlsson, E. Nordberg; Brumer, H. ; Ohlin, M. Engineered Xyloglucan Specificity In A Carbohydrate-Binding Module. GLYCOBIOLOGY 2006, 16, 1171-1180.
Neustroev, K. N. ; Golubev, A. M. ; Sinnott, M. L. ; Borriss, R. ; Krah, M. ; Brumer, H. ; Eneyskaya, E. V. ; Shishlyannikov, S. ; Shabalin, K. A. ; Peshechonov, V. T. ; Korolev, V. G. ; Kulminskaya, A. A. Transferase And Hydrolytic Activities Of The Laminarinase From Rhodothermus Marinus And Its M133A, M133C, And M133W Mutants. GLYCOCONJUGATE JOURNAL 2006, 23, 501-511.
Zhou, Q. ; Baumann, M. J. ; Brumer, H. ; Teeri, T. T. The Influence Of Surface Chemical Composition On The Adsorption Of Xyloglucan To Chemical And Mechanical Pulps. CARBOHYDRATE POLYMERS 2006, 63, 449-458.
Stiernstedt, J. ; Nordgren, N. ; Wagberg, L. ; Brumer, H. ; Gray, D. G. ; Rutland, M. W. Friction And Forces Between Cellulose Model Surfaces: A Comparison. JOURNAL OF COLLOID AND INTERFACE SCIENCE 2006, 303, 117-123.
Zhou, Q. ; Baumann, M. J. ; Piispanen, P. S. ; Teeri, T. T. ; Brumer, H. Xyloglucan And Xyloglucan Endo-Transglycosylases (Xet): Tools For Ex Vivo Cellulose Surface Modification. BIOCATALYSIS AND BIOTRANSFORMATION 2006, 24, 107-120.
Martinez-Fleites, C. ; Guerreiro, C. I. P. D. ; Baumann, M. J. ; Taylor, E. J. ; Prates, J. A. M. ; Ferreira, L. M. A. ; Fontes, C. M. G. A. ; Brumer, H. ; Davies, G. J. Crystal Structures Of Clostridium Thermocellum Xyloglucanase, Xgh74A, Reveal The Structural Basis For Xyloglucan Recognition And Degradation. JOURNAL OF BIOLOGICAL CHEMISTRY 2006, 281, 24922-24933.
Saura-Valls, M. ; Faure, R. ; Ragas, S. ; Piens, K. ; Brumer, H. ; Teeri, T. T. ; Cottaz, S. ; Driguez, H. ; Planas, A. Kinetic Analysis Using Low-Molecular Mass Xyloglucan Oligosaccharides Defines The Catalytic Mechanism Of A Populus Xyloglucan Endotransglycosylase. BIOCHEMICAL JOURNAL 2006, 395, 99-106.
Stiernstedt, J. ; Brumer, H. ; Zhou, Q. ; Teeri, T. T. ; Rutland, M. W. Friction Between Cellulose Surfaces And Effect Of Xyloglucan Adsorption. BIOMACROMOLECULES 2006, 7, 2147-2153.
Lonnberg, H. ; Zhou, Q. ; Brumer, H. ; Teeri, T. T. ; Malmstrom, E. ; Hult, A. Grafting Of Cellulose Fibers With Poly(Epsilon-Caprolactone) And Poly(L-Lactic Acid) Via Ring-Opening Polymerization. BIOMACROMOLECULES 2006, 7, 2178-2185.
Faure, R. ; Saura-Valls, M. ; Brumer, H. ; Planas, A. ; Cottaz, S. ; Driguez, H. Synthesis Of A Library Of Xylogluco-Oligosaccharides For Active-Site Mapping Of Xyloglucan Endo-Transglycosylase. JOURNAL OF ORGANIC CHEMISTRY 2006, 71, 5151-5161.

2005

Ghebremichael, K. A. ; Gunaratna, K. R. ; Henriksson, H. ; Brumer, H. ; Dalhammar, G. A Simple Purification And Activity Assay Of The Coagulant Protein From Moringa Oleifera Seed. WATER RESEARCH 2005, 39, 2338-2344.
Zhou, Q. ; Greffe, L. ; Baumann, M. J. ; Malmstrom, E. ; Teeri, T. T. ; Brumer, H. Use Of Xyloglucan As A Molecular Anchor For The Elaboration Of Polymers From Cellulose Surfaces: A General Route For The Design Of Biocomposites. MACROMOLECULES 2005, 38, 3547-3549.
Greffe, L. ; Bessueille, L. ; Bulone, V. ; Brumer, H. Synthesis, Preliminary Characterization, And Application Of Novel Surfactants From Highly Branched Xyloglucan Oligosaccharides. GLYCOBIOLOGY 2005, 15, 437-445.
Gustavsson, M. T. ; Persson, P. V. ; Iversen, T. ; Martinelle, M. ; Hult, K. ; Teeri, T. T. ; Brumer, H. Modification Of Cellulose Fiber Surfaces By Use Of A Lipase And A Xyloglucan Endotransglycosylase. BIOMACROMOLECULES 2005, 6, 196-203.
Eneyskaya, E. V. ; Ivanen, D. R. ; Shabalin, K. A. ; Kulminskaya, A. A. ; Backinowsky, L. V. ; Brumer, H. ; Neustroev, K. N. Chemo-Enzymatic Synthesis Of 4-Methylumbelliferyl Beta-(1 -> 4)-D-Xylooligosides: New Substrates For Beta-D-Xylanase Assays. ORGANIC & BIOMOLECULAR CHEMISTRY 2005, 3, 146-151.
Uhlen, M. ; Bjorling, E. ; Agaton, C. ; Szigyarto, C. A. ; Amini, B. ; Andersen, E. ; Andersson, A. C. ; Angelidou, P. ; Asplund, A. ; Asplund, C. ; Berglund, L. ; Bergstrom, K. ; Brumer, H. ; Cerjan, D. ; Ekstrom, M. ; Elobeid, A. ; Eriksson, C. ; Fagerberg, L. ; Falk, R. ; Fall, J. ; Forsberg, M. ; Bjorklund, M. G. ; Gumbel, K. ; Halimi, A. ; Hallin, I. ; Hamsten, C. ; Hansson, M. ; Hedhammar, M. ; Hercules, G. ; Kampf, C. ; Larsson, K. ; Linskog, M. ; Lodewyckx, W. ; Lund, J. ; Lundeberg, J. ; Magnusson, K. ; Malm, E. ; Nilsson, P. ; Odling, J. ; Oksvold, P. ; Olsson, I. ; Oster, E. ; Ottosson, J. ; Paavilainen, L. ; Persson, A. ; Rimini, R. ; Rockberg, J. ; Runeson, M. ; Sivertsson, A. ; Skollermo, A. ; Steen, J. ; Stenvall, M. ; Sterky, F. ; Stromberg, S. ; Sundberg, M. ; Tegel, H. ; Tourle, S. ; Wahlund, E. ; Walden, A. ; Wan, J. H. ; Wernerus, H. ; Westberg, J. ; Wester, K. ; Wrethagen, U. ; Xu, L. L. ; Hober, S. ; Ponten, F. A Human Protein Atlas For Normal And Cancer Tissues Based On Antibody Proteomics. MOLECULAR & CELLULAR PROTEOMICS 2005, 4, 1920-1932.
Kallas, A. M. ; Piens, K. ; Denman, S. E. ; Henriksson, H. ; Faldt, J. ; Johansson, P. ; Brumer, H. ; Teeri, T. T. Enzymatic Properties Of Native And Deglycosylated Hybrid Aspen (Populus Tremula X Tremuloides) Xyloglucan Endotransglycosylase 16A Expressed In Pichia Pastoris. BIOCHEMICAL JOURNAL 2005, 390, 105-113.
Engfeldt, T. ; Renberg, B. ; Brumer, H. ; Nygren, P. A. ; Karlstrom, A. E. Chemical Synthesis Of Triple-Labelled Three-Helix Bundle Binding Proteins For Specific Fluorescent Detection Of Unlabelled Protein. CHEMBIOCHEM 2005, 6, 1043-1050.

2004

Campuzano, L. ; Brumer, H. ; Piens, K. ; Sage, A. ; Mckenna, T. ; Langridge, J. Accurate Mass Analysis Of Glycoprotein Isoforms By Electrospray Ionisation, Orthogonal Acceleration Time-Of-Flight Mass Spectrometry And Maximum Entropy. MOLECULAR & CELLULAR PROTEOMICS 2004, 3, S130.
Brumer, H. ; Zhou, Q. ; Baumann, M. J. ; Carlsson, K. ; Teeri, T. T. Activation Of Crystalline Cellulose Surfaces Through The Chemoenzymatic Modification Of Xyloglucan. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2004, 126, 5715-5721.
Eriksson, T. ; Stals, I. ; Collen, A. ; Tjerneld, F. ; Claeyssens, M. ; Stalbrand, H. ; Brumer, H. Heterogeneity Of Homologously Expressed Hypocrea Jecorina (Trichoderma Reesei) Cel7B Catalytic Module. EUROPEAN JOURNAL OF BIOCHEMISTRY 2004, 271, 1266-1276.
Johansson, P. ; Brumer, H. ; Baumann, M. J. ; Kallas, A. M. ; Henriksson, H. ; Denman, S. E. ; Teeri, T. T. ; Jones, T. A. Crystal Structures Of A Poplar Xyloglucan Endotransglycosylase Reveal Details Of Transglycosylation Acceptor Binding. PLANT CELL 2004, 16, 874-886.
Henriksson, H. ; Denman, S. E. ; Campuzano, I. D. G. ; Ademark, P. ; Master, E. R. ; Teeri, T. T. ; Brumer, H. N-Linked Glycosylation Of Native And Recombinant Cauliflower Xyloglucan Endotransglycosylase 16A (Vol 375, Pg 61, 2003). BIOCHEMICAL JOURNAL 2004, 378, 1095.

2003

Henriksson, H. ; Denman, S. E. ; Campuzano, I. D. G. ; Ademark, P. ; Master, E. R. ; Teeri, T. T. ; Brumer, H. N-Linked Glycosylation Of Native And Recombinant Cauliflower Xyloglucan Endotransglycosylase 16A. BIOCHEMICAL JOURNAL 2003, 375, 61-73.
Teeri, T. T. ; Brumer, H. Discovery, Characterisation And Applications Of Enzymes From The Wood-Forming Tissues Of Poplar: Glycosyl Transferases And Xyloglucan Endotransglycosylases. BIOCATALYSIS AND BIOTRANSFORMATION 2003, 21, 173-179.
Borriss, R. ; Krah, M. ; Brumer, H. ; Kerzhner, M. A. ; Ivanen, D. R. ; Eneyskaya, E. V. ; Elyakova, L. A. ; Shishlyannikov, S. M. ; Shabalin, K. A. ; Neustroev, K. N. Enzymatic Synthesis Of 4-Methylumbelliferyl (1 -> 3)-Beta-D-Glucooligosaccharides - New Substrates For Beta-1,3-1,4-D-Glucanase. CARBOHYDRATE RESEARCH 2003, 338, 1455-1467.
Johansson, P. ; Denman, S. ; Brumer, H. ; Kallas, A. M. ; Henriksson, H. ; Bergfors, T. ; Teeri, T. T. ; Jones, T. A. Crystallization And Preliminary X-Ray Analysis Of A Xyloglucan Endotransglycosylase From Populus Tremula X Tremuloides. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 2003, 59, 535-537.
Eneyskaya, E. V. ; Brumer, H. ; Backinowsky, L. V. ; Ivanen, D. R. ; Kulminskaya, A. A. ; Shabalin, K. A. ; Neustroev, K. N. Enzymatic Synthesis Of Beta-Xylanase Substrates: Transglycosylation Reactions Of The Beta-Xylosidase From Aspergillus Sp. CARBOHYDRATE RESEARCH 2003, 338, 313-325.
Christiernin, M. ; Henriksson, G. ; Lindstrom, M. E. ; Brumer, H. ; Teeri, T. T. ; Lindstrom, T. ; Laine, J. The Effects Of Xyloglucan On The Properties Of Paper Made From Bleached Kraft Pulp. NORDIC PULP & PAPER RESEARCH JOURNAL 2003, 18, 182-187.

2002

Bourquin, V. ; Nishikubo, N. ; Abe, H. ; Brumer, H. ; Denman, S. ; Eklund, M. ; Christiernin, M. ; Teeri, T. T. ; Sundberg, B. ; Mellerowicz, E. J. Xyloglucan Endotransglycosylases Have A Function During The Formation Of Secondary Cell Walls Of Vascular Tissues. PLANT CELL 2002, 14, 3073-3088.
Brumer, H. Carbohydrases. In The Encyclopedia of Catalysis; Horváth, I. T. ; The Encyclopedia of Catalysis; John Wiley and Sons: New York, 2002.

2001

Brun, E. ; Brumer, H. ; MacKenzie, L. F. ; Withers, S. G. ; McIntosh, L. P. Letter To The Editor: Assignment Of Selectively C-13-Labeled Cellopentaose Synthesized Using An Engineered Glycosynthase. JOURNAL OF BIOMOLECULAR NMR 2001, 21, 67-68.
Becker, D. ; Braet, C. ; Brumer, H. ; Claeyssens, M. ; Divne, C. ; Fagerstrom, B. R. ; Harris, M. ; Jones, T. A. ; Kleywegt, G. J. ; Koivula, A. ; Mahdi, S. ; Piens, K. ; Sinnott, M. L. ; Stahlberg, J. ; Teeri, T. T. ; Underwood, M. ; Wohlfahrt, G. Engineering Of A Glycosidase Family 7 Cellobiohydrolase To More Alkaline Ph Optimum: The Ph Behaviour Of Trichoderma Reesei Cei7A And Its E223S/a224H/l225V/t226A/d262G Mutant. BIOCHEMICAL JOURNAL 2001, 356, 19-30.

2000

Hart, D. O. ; He, S. M. ; Chany, C. J. ; Withers, S. G. ; Sims, P. F. G. ; Sinnott, M. L. ; Brumer, H. Identification Of Asp-130 As The Catalytic Nucleophile In The Main Alpha-Galactosidase From Phanerochaete Chrysosporium, A Family 27 Glycosyl Hydrolase. BIOCHEMISTRY 2000, 39, 9826-9836.

1999

Brumer, H. ; Sims, P. F. G. ; Sinnott, M. L. Lignocellulose Degradation By Phanerochaete Chrysosporium: Purification And Characterization Of The Main Alpha-Galactosidase. BIOCHEMICAL JOURNAL 1999, 339, 43-53.

1995

Moriarty, R. M. ; Brumer, H. Toward A General Synthesis Of A-Ring Trihydroxylated Vitamin D Analogs: Synthesis Of An A-Ring Synthon Of Ed-71 From D-Arabinose. TETRAHEDRON LETTERS 1995, 36, 9265-9268.
Moriarty, R. M. ; KIM, J. ; Brumer, H. A General Synthetic Route To A-Ring Hydroxylated Vitamin-D Analogs From Pentoses. TETRAHEDRON LETTERS 1995, 36, 51-54.