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David Chen

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Research and Teaching Interests

Our research program is built on the premise that chemical separation is driven by physical field and chemical equilibrium.  With the insights into how molecules are separated and detected in capillary columns, we wish to design novel instrument that can provide even more separation power for chemical analysis and purification.  Interestingly, the newly designed instrument comes with newly created problems to be solved, and new phenomena to be explained.  Our group enjoys meeting these challenges with many wonderful tools available to us, including what we have learned in physics, mathematics, computer science, and most importantly, chemistry!  We have several projects currently being worked on:

Interface development for capillary electrophoresis- electrospray ionization – mass spectrometry (CE-ESI-MS)
Currently available interfaces suffer from several deficiencies stemmed from the lack of understanding of the fundamental processes involved in CE and MS separately, as well as when the two techniques are interfaced. By playing with the shape and geometry of the sprayer, the chemical properties of the surfaces, solution compositions and the electrical circuits that drive the processes we are developing novel CE-MS interfaces that we hope will give improved performance in both the separation and detection.

Electrophoretic strategies for the purification of biomolecules
In this project we are designing novel instrumentation for larger scale purification systems based on the infinite resolution theory we developed in the past.  By balancing the electrophoretic and hydrodynamic forces acting on analytes in solution, we can selectively manipulate their trajectory.  Having established this technology in single capillaries, we are now working to understand how we can use novel geometries to improve the capacity and yield of purification.

Affinity capillary electrophoresis for the characterization of biochemical interactions
Capillary electrophoresis is an excellent tool for studying biochemical interactions because the separation environment can be tailored to simulate in vivo conditions.  Our group has developed several different techniques that can be used to determine the binding constants based on simple affinity CE experiments.  In addition to applying this technology to many important biological problems, we have also developed software that allows us to visualize what is occurring in the capillary at every stage of an affinity separation, and to predict future results.  The focus now is on improving the predictive ability of the software to allow us to study more complex interactions.

Quantitative investigation of anesthetic agents and markers of oxidative stress in human blood
This project is in collaboration with a Dr. David Ansley at the Vancouver General Hospital, and is designed to study the dose-dependent cardioprotective potential mechanism of propofol. We have developed a quantitative capillary electrophoresis based method to get an accurate picture of how the concentration of anesthetic in a patient’s blood can affect their resilience to oxidative stress and subsequent recovery.

With the beautiful weather in the summer and mild temperature all year round, Vancouver is the most attractive place in North America to live and study. Our group is truly blessed with a very exciting environment to grow both academically and personally.

Prospective students?
We are always welcoming enthusiastic individuals into our lab.  Although our focus is on chemical separations, diverse backgrounds including physics, math, computer studies and biology all have a chance to make unique contributions.   The only pre-requisite is a willingness to learn.  Interested students should contact David at .

David D. Y.Chen Google Scholar Citations

Contact

Real name: 
David Chen
Email: 
Office Room Number(s): 
Chemistry A347
Office Phone Number: 
604-822-0878

Curriculum Vitae

B.Sc., Xiamen (1985); Ph.D., Alberta (N.J. Dovichi, 1993); Postdoctoral, Alberta (N.J. Dovichi, J.F. Elliott, 1993-1994), Royal Society of Chemistry Award in Analytical Separation Methods (2001), UBC Charles A. McDowell Award for Excellence in Research (2002), Canadian Society for Chemistry W. A. E. McBryde Medal (2008), Canadian Society for Chemistry Maxxam Award (2015)

Google Scholar Citations

Publications

2024

Shi, M. ; Huang, C. ; Chen, R. ; Chen, D. D. Y. ; Yan, B. A New Evaluation Metric For Quantitative Accuracy Of Lc–Ms/ms-Based Proteomics With Data-Independent Acquisition. Journal of Proteome Research 2024, in press.
Liao, Y. ; Ge, W. ; Liu, M. ; Bi, W. ; Jin, C. ; Chen, D. Da Yong Eco-Friendly Regeneration Of Lignin With Acidic Deep Eutectic Solvent For Adsorption Of Pollutant Dyes For Water Cleanup. International Journal of Biological Macromolecules 2024, 260, 129677.
Wang, Z. ; Ge, W. ; Bi, W. ; Chen, D. Da Yong Strategies For Using Magnetic Beads In Enhanced Deep Eutectic Solvent-Mechanochemical Extraction Of Natural Products From Orange Peels. Food Chemistry 2024, 447, 139004.
Chenyakin, Y. ; Chen, D. D. Y. Numerical Modeling And Experimental Optimization Of Taylor Dispersion Analysis With And Without An Electric Field. ELECTROPHORESIS 2024, 45, 1054 - 1064.
Li, Y. ; Miao, S. ; Tan, J. ; Zhang, Q. ; Chen, D. D. Y. Capillary Electrophoresis: A Three-Year Literature Review. Analytical Chemistry 2024, in press.
Tang, H. ; Wang, Y. ; Si, S. ; Li, H. ; Chen, D. D. Y. Quantification Of Perfluorinated Compounds In Atmospheric Particulate Shows Potential Connection With Environmental Event. Journal of Environmental Sciences 2024, 136, 237-247.
Cai, S. ; Su, Y. ; Shi, M. ; Wang, D. ; Chen, D. D. Y. ; Yan, B. Simultaneous Quantification Of Six Proteins Related To Liver Injury Using Nano Liquid Chromatography–Tandem Mass Spectrometry. Rapid Communications in Mass Spectrometry 2024, 38, e9754.
Bai, Z. ; Zhao, Z. ; Wang, S. ; Li, H. ; Chen, D. D. Y. Ambient Mass Spectrometry Imaging Of Food Natural Products By Angled Direct Analysis In Real Time High-Resolution Mass Spectrometry. Food Chemistry 2024, 454, 139802.
Geng, X. ; Wang, Y. ; Li, H. ; Chen, D. D. Y. Characterization Of Cigarette Smokeomics By In Situ Solid-Phase Microextraction And Confined-Space Direct Analysis In Real Time Mass Spectrometry. Talanta 2024, 126680.

2023

Geng, X. ; Zhang, K. ; Li, H. ; Chen, D. D. Y. Online Mass Spectrometry Of Exhaled Breath With A Modified Ambient Ion Source. Talanta 2023, 124254.
Ren, R. ; Yuan, M. ; Li, H. ; Chen, D. D. Y. Direct Identification Of Disaccharide Structural Isomers Using Ambient Ionization Tandem Mass Spectrometry With In Situ Methylation. Analytical Chemistry 2023, 95, 2213 - 2220.
Liu, M. ; Wang, S. ; Ge, W. ; Bi, W. ; Chen, D. D. Y. Influence Of Host–Guest Interactions On Analytical Performance Of Direct Analysis In Real-Time Mass Spectrometry. Analytical and Bioanalytical Chemistry 2023.
Dai, Y. ; Sun, C. ; Yang, Y. ; Wang, S. ; Li, H. ; Chen, D. D. Y. Β-Cyclodextrin And Folic Acid Host–Guest Interaction Binding Parameters Determined By Taylor Dispersion Analysis And Affinity Capillary Electrophoresis. ELECTROPHORESIS 2023, 44.
Zhang, Y. ; Yu, L. ; Ge, W. ; Bi, W. ; Chen, D. D. Y. Preparation Of Carbon-Rich Material From Dendrobium Officinale Polysaccharide In Deep Eutectic System. International Journal of Biological Macromolecules 2023, 253, 127394.
Yan, B. ; Shi, M. ; Cai, S. ; Su, Y. ; Chen, R. ; Huang, C. ; Chen, D. D. Y. Data-Driven Tool For Cross-Run Ion Selection And Peak-Picking In Quantitative Proteomics With Data-Independent Acquisition Lc–Ms/ms. Analytical Chemistry 2023, in press.
Liu, M. ; Wang, S. ; Bi, W. ; Chen, D. D. Y. Plant Polysaccharide Itself As Hydrogen Bond Donor In A Deep Eutectic System-Based Mechanochemical Extraction Method. Food Chemistry 2023, 399, 133941.

2022

Ramautar, R. ; Chen, D. D. Y. Capillary Electrophoresis - Mass Spectrometry For Proteomics And Metabolomics: Principles And Applications; 1st ed.; Wiley-VCH, 2022; p. 400.
Zhong, J. J. ; Morin, G. B. ; Chen, D. D. Y. Data-Processing Workflow For Relative Quantification From Label-Free And Isobaric Labeling-Based Untargeted Shotgun Proteomics: From Database Search To Differential Expression Analysis. In Capillary Electrophoresis‐Mass Spectrometry for Proteomics and Metabolomics; Capillary Electrophoresis‐Mass Spectrometry for Proteomics and Metabolomics; John Wiley & Sons, Ltd, 2022; pp. 65-119.
Tan, J. ; Huang, Z. - A. ; Morin, G. B. ; Chen, D. D. Y. Data Processing In Metabolomics Capillary Electrophoresis–Mass Spectrometry. In Capillary Electrophoresis‐Mass Spectrometry for Proteomics and Metabolomics; Capillary Electrophoresis‐Mass Spectrometry for Proteomics and Metabolomics; John Wiley & Sons, Ltd, 2022; pp. 121-145.
Yahaya, N. ; Huang, Z. - A. ; Yan, B. ; Chen, D. D. Y. Capillary Electrophoresis–Mass Spectrometry Analysis Of Bisphenol A And Its Analogues In Bottled Tea Beverages With Dynamic Ph Focusing. Food Chemistry 2022, 372, 131220.
Huang, Z. - A. ; Tan, J. ; Li, Y. ; Miao, S. ; Scotland, K. B. ; Chew, B. H. ; Lange, D. ; Chen, D. D. Y. Migration Time Correction For Dual Pressure Capillary Electrophoresis In Semi-Targeted Metabolomics Study. ELECTROPHORESIS 2022, 43, 1626-1637.
Cao, X. ; Liu, M. ; Bi, W. ; Lin, J. ; Chen, D. D. Y. Direct Carboxylation Of Cellulose In Deep Eutectic Solvent And Its Adsorption Behavior Of Methylene Blue. Carbohydrate Polymer Technologies and Applications 2022, 100222.
Cao, D. ; Liu, M. ; Su, Y. - C. ; Yang, Z. ; Bi, W. ; Chen, D. D. Y. Adsorption Behavior Of Anthraquinones In Deep Eutectic Solvent On Polyester Fiber And Its Application. Sustainable Chemistry and Pharmacy 2022, 27, 100680.
Semail, N. - F. ; Keyon, A. Syazwani A. ; Saad, B. ; Kamaruzaman, S. ; Zain, N. Nadhirah M. ; Lim, V. ; Miskam, M. ; Abdullah, W. Nazwanie W. ; Yahaya, N. ; Chen, D. D. Y. Simultaneous Preconcentration And Determination Of Sulfonamide Antibiotics In Milk And Yoghurt By Dynamic Ph Junction Focusing Coupled With Capillary Electrophoresis. Talanta 2022, 236, 122833.
Xu, L. ; Zhang, K. ; Geng, X. ; Li, H. ; Chen, D. D. Y. High Resolution Mass Spectrometry Exhalome Profiling With A Modified Direct Analysis In Real Time Ion Source. Rapid Communications in Mass Spectrometry 2022, n/a, e9406.
Ren, R. ; Li, H. ; Jiang, Q. ; Wang, X. ; Chen, D. D. Y. Characterization Of Ginsenoside Structural Isomers From Mixtures Using In Situ Methylation With Direct Analysis In Real-Time Ionization Tandem Mass Spectrometry. Analytical and Bioanalytical Chemistry 2022.

2021

Chaihu, L. ; Yao, X. ; Xu, X. ; Zhu, Z. ; Chen, D. D. Y. ; Wang, G. Capillary Electrophoresis-Based Hydrogen/deuterium Exchange For Conformational Characterization Of Proteins With Top-Down Mass Spectrometry. J. Vis. Exp. 2021, 172, e62672.
Chen, Q. ; Chaihu, L. ; Yao, X. ; Cao, X. ; Bi, W. ; Lin, J. ; Chen, D. D. Y. Molecular Property-Tailored Soy Protein Extraction Process Using A Deep Eutectic Solvent. ACS Sustainable Chemistry & Engineering 2021, 9, 10083-10092.
Chenyakin, Y. ; Chen, D. D. Y. Characterization Of Capillary Inner Surface Conditions With Streaming Potential. ELECTROPHORESIS 2021, 42, 2094 - 2102.
Liu, M. ; Cao, D. ; Bi, W. ; Chen, D. D. Y. Extraction Of Natural Products By Direct Formation Of Eutectic Systems. ACS Sustainable Chemistry & Engineering 2021, 9, 12049−12057.
Ge, Z. ; Zhang, K. ; Chen, D. D. Y. ; Yan, B. Data-Driven Development Of Liquid Chromatography-Mass Spectrometry Methods For Combined Sample Matrices. Talanta 2021, 224, 121880.
Wang, X. ; Jiang, Q. ; Li, H. ; Chen, D. D. Y. Rapid Fingerprint Analysis For Herbal Polysaccharides Using Direct Analysis In Real-Time Ionization Mass Spectrometry. Rapid Communications in Mass Spectrometry 2021, 35, e9139.
Zhao, T. ; Wang, L. ; Li, Y. ; Chen, S. ; Wang, R. ; Chen, D. D. Y. Quantification Of The Bisphosphonate Alendronate Using Capillary Electrophoresis Mass Spectrometry With Dynamic Ph Barrage Junction Focusing. ELECTROPHORESIS 2021, 42, 350–359.
Hassan, F. Wahidah Mo; Raoov, M. ; Kamaruzaman, S. ; Mohamed, A. Husaini; Ibrahim, W. Nazihah Wa; Hanapi, N. Suhaila Mo; Zain, N. Nadhirah M. ; Yahaya, N. ; Chen, D. Da Yong A Rapid And Efficient Dispersive Trehalose Biosurfactant Enhanced Magnetic Solid Phase Extraction For The Sensitive Determination Of Organophosphorus Pesticides In Cabbage (Brassica Olearaceae Var. Capitate) Samples By Gc-Fid. Journal of Food Composition and Analysis 2021, 102, 104057.
Jing, W. ; Wang, J. ; Kuipers, B. ; Bi, W. ; Chen, D. D. Y. Recent Applications Of Graphene And Graphene-Based Materials As Sorbents In Trace Analysis. TrAC Trends in Analytical Chemistry 2021, 137, 116212.
Meulen, I. J. Vander; Klemish, J. L. ; Peru, K. M. ; Chen, D. D. Y. ; Pyle, G. G. ; Headley, J. V. Molecular Profiles Of Naphthenic Acid Fraction Compounds From Mine Lease Wetlands In The Athabasca Oil Sands Region. Chemosphere 2021, 272, 129892.
Wang, S. ; Yang, Y. ; Yang, Y. ; Li, H. ; Chen, D. D. Y. Quantitative Characterization Of Human Oncogene Promoter G-Quadruplex Dna-Ligand Interactions Using A Combination Of Mass Spectrometry And Capillary Electrophoresis. ELECTROPHORESIS 2021, 42, 1450-1460.
Geng, X. ; Zhao, Z. ; Li, H. ; Chen, D. D. Y. Tee-Shaped Sample Introduction Device Coupled With Direct Analysis In Real-Time Mass Spectrometry For Gaseous Analytes. Analytical Chemistry 2021, 93, 16813-16820.
Yang, Y. ; Yang, Y. ; Wang, S. ; Li, H. ; Chen, D. D. Y. Detecting The Formation Of Human C-Kit Oncogene Promoter G-Quadruplex By Taylor Dispersion Analysis. Talanta 2021, 233, 122533.

2020

Huang, Z. - A. ; Scotland, K. B. ; Li, Y. ; Tan, J. ; Kung, S. H. Y. ; Chew, B. H. ; Chen, D. D. Y. ; Lange, D. Determination Of Urinary Prostaglandin E2 As A Potential Biomarker Of Ureteral Stent Associated Inflammation. Journal of Chromatography B 2020, 1145, 122107.
Cheng, J. ; Wang, L. ; Rive, C. M. ; Holt, R. A. ; Morin, G. B. ; Chen, D. D. Y. Complementary Methods For De Novo Monoclonal Antibody Sequencing To Achieve Complete Sequence Coverage. Journal of Proteome Research 2020, 19, 2700 - 2707.
Yang, S. - S. ; Wang, C. ; Yu, X. ; Shang, W. ; Chen, D. D. Y. ; Gu, Z. - Y. A Hydrophilic Two-Dimensional Titanium-Based Metal-Organic Framework Nanosheets For Specific Enrichment Of Glycopeptides. Analytica Chimica Acta 2020, 1119, 60 - 67.
Wang, L. ; Cheng, J. ; McNutt, J. E. ; Morin, G. B. ; Chen, D. D. Y. Dynamic Ph Barrage Junction Focusing Of Amino Acids, Peptides, And Digested Monoclonal Antibodies In Capillary Electrophoresis–Mass Spectrometry. ELECTROPHORESIS 2020, 41, 1832 - 1842.
Yan, B. ; Huang, Z. - A. ; Yahaya, N. ; Chen, D. D. Y. Enantioselective Analysis In Complex Matrices Using Capillary Electrophoresis-Mass Spectrometry: A Case Study Of The Botanical Drug Corydalis Rhizoma. Journal of Chromatography B 2020, 1152, 122216.
Jiang, Q. ; Wang, Y. ; Li, H. ; Chen, D. D. Y. Combining Online Size Exclusion Chromatography And Electrospray Ionization Mass Spectrometry To Characterize Plant Polysaccharides. Carbohydrate Polymers 2020, 246, 116591.
Zhao, T. ; Wang, L. ; Chen, D. D. Y. Quantification Of Imatinib And Related Compounds Using Capillary Electrophoresis-Tandem Mass Spectrometry With Field-Amplified Sample Stacking. ELECTROPHORESIS 2020, 41, 1843-1850.
Wang, J. ; Jing, W. ; Tian, H. ; Liu, M. ; Yan, H. ; Bi, W. ; Chen, D. D. Y. Investigation Of Deep Eutectic Solvent-Based Microwave-Assisted Extraction And Efficient Recovery Of Natural Products. ACS Sustainable Chemistry & Engineering 2020, 8, 12080–12088.
Cao, D. ; Liu, Q. ; Jing, W. ; Tian, H. ; Yan, H. ; Bi, W. ; Jiang, Y. ; Chen, D. D. Y. Insight Into The Deep Eutectic Solvent Extraction Mechanism Of Flavonoids From Natural Plant. ACS Sustainable Chemistry & Engineering 2020, 8, 19169-19177.
Jing, W. ; Zhou, Y. ; Wang, J. ; Zhu, Y. ; Lv, Y. ; Bi, W. ; Chen, D. D. Y. Sorbent And Solvent Co-Enhanced Direct Analysis In Real Time-Mass Spectrometry For High-Throughput Determination Of Trace Pollutants In Water. Talanta 2020, 208, 120378.
Cheng, J. ; Morin, G. B. ; Chen, D. D. Y. Bottom-Up Proteomics Of Envelope Proteins Extracted From Spinach Chloroplast Via High-Organic-Content Capillary Electrophoresis-Mass Spectrometry. ELECTROPHORESIS 2020, 41, 370-378.
Wang, X. ; Jiang, Q. ; Li, H. ; Chen, D. D. Y. Rapid Determination Of Chemical Composition In The Particulate Matter Of Cigarette Mainstream Smoke. Talanta 2020, 217, 121060.
Huang, Z. - A. ; Scotland, K. B. ; Li, Y. ; Guo, J. - P. ; McGeer, P. L. ; Lange, D. ; Chen, D. D. Y. Application Of Multisegment Injection On Quantification Of Creatinine And Standard Addition Analysis Of Urinary 5-Hydroxyindoleacetic Acid Simultaneously With Creatinine Normalization. ELECTROPHORESIS 2020, 41, 183-193.
Yang, Y. ; Fu, H. ; Qian, C. ; Li, H. ; Chen, D. D. Y. Characterization Of Interaction Between Bcl-2 Oncogene Promoter I-Motif Dna And Flavonoids Using Electrospray Ionization Mass Spectrometry And Pressure-Assisted Capillary Electrophoresis Frontal Analysis. Talanta 2020, 120885.

2019

Fu, H. ; Qian, C. ; Tong, W. ; Li, H. ; Chen, D. D. Y. Mass Spectrometry And Affinity Capillary Electrophoresis For Characterization Of Host-Guest Interactions. Journal of Chromatography A 2019, 1589, 182-190.
Shen, Y. ; Zhao, X. ; Wang, G. ; Chen, D. D. Y. Differential Hydrogen/deuterium Exchange During Proteoform Separation Enables Characterization Of Conformational Differences Between Coexisting Protein States. Analytical Chemistry 2019, 91, 3805-3809.
Kovalchik, K. A. ; Colborne, S. ; Spencer, S. Elizabeth; Sorensen, P. H. ; Chen, D. D. Y. ; Morin, G. B. ; Hughes, C. S. Rawtools: Rapid And Dynamic Interrogation Of Orbitrap Data Files For Mass Spectrometer System Management. Journal of Proteome Research 2019, 18, 700-708.
Yang, P. ; Wang, X. ; Gu, Z. ; Li, H. ; Chen, D. D. Y. ; Yang, X. Evaluation Of The Binding Of Natural Products With Thrombin Binding Aptamer G-Quadruplex Using Electrospray Ionization Mass Spectrometry And Spectroscopic Methods. Talanta 2019, 200, 424-431.
Zhou, Y. ; Zhu, J. ; Yang, J. ; Lv, Y. ; Zhu, Y. ; Bi, W. ; Yang, X. ; Chen, D. D. Y. Magnetic Nanoparticles Speed Up Mechanochemical Solid Phase Extraction With Enhanced Enrichment Capability For Organochlorines In Plants. Analytica Chimica Acta 2019, 1066, 49-57.
Tian, H. ; Wang, J. ; Li, Y. ; Bi, W. ; Chen, D. D. Y. Recovery Of Natural Products From Deep Eutectic Solvents By Mimicking Denaturation. ACS Sustainable Chemistry & Engineering 2019, 7, 9976-9983.
Yan, P. ; Zhang, K. ; Wang, L. ; Tong, W. ; Chen, D. D. Y. Quantitative Analysis Of Microcystin Variants By Capillary Electrophoresis Mass Spectrometry With Dynamic Ph Barrage Junction Focusing. Electrophoresis 2019, 40, 2285-2293.
Wang, M. ; Dubiak, K. ; Zhang, Z. ; Huber, P. ; Chen, D. D. Y. ; Dovichi, N. J. Maldi-Imaging Of Early Stage Xenopus Laevis Embryos. Talanta 2019, 204, 138-144.
Wang, J. ; Du, Q. ; You, X. ; Lv, Y. ; Bi, W. ; Li, H. ; Chen, D. D. Y. Solvent-Free High-Throughput Analysis Of Herbicides In Environmental Water. Analytica Chimica Acta 2019, 1071, 8 - 16.
Jing, W. ; Zhou, Y. ; Wang, J. ; Ni, M. ; Bi, W. ; Chen, D. D. Y. Dispersive Magnetic Solid-Phase Extraction Coupled To Direct Analysis In Real Time Mass Spectrometry For High-Throughput Analysis Of Trace Environmental Contaminants. Analytical Chemistry 2019, 91, 11240-11246.
Wang, L. ; Chen, D. D. Y. Analysis Of Four Therapeutic Monoclonal Antibodies By Online Capillary Isoelectric Focusing Directly Coupled To Quadrupole Time-Of-Flight Mass Spectrometry. ELECTROPHORESIS 2019, 40, 2899-2907.
Jiang, Q. ; Dai, D. ; Li, H. ; Chen, D. D. Y. Simultaneous Determination Of Multiple Components In Cigarettes By Mechanochemical Extraction And Direct Analysis In Real Time Mass Spectrometry In Minutes. Analytica Chimica Acta 2019, 1057, 70-79.

2018

Cheng, J. ; Chen, D. D. Y. Nonaqueous Capillary Electrophoresis Mass Spectrometry Method For Determining Highly Hydrophobic Peptides. Electrophoresis 2018, 39, 1216-1221.
MacLennan, M. S. ; Kok, M. G. M. ; Soliman, L. ; So, A. ; Hurtado-Coll, A. ; Chen, D. D. Y. Capillary Electrophoresis-Mass Spectrometry For Targeted And Untargeted Analysis Of The Sub-5 Kda Urine Metabolome Of Patients With Prostate Or Bladder Cancer: A Feasibility Study. Journal of Chromatography B 2018, 1074–1075, 79 - 85.
Zhao, X. ; Shen, Y. ; Tong, W. ; Wang, G. ; Chen, D. Da Yong Deducing Disulfide Patterns Of Cysteine-Rich Proteins Using Signature Fragments Produced By Top-Down Mass Spectrometry. Analyst 2018, 143, 817-823.
Wang, J. ; Zhou, Y. ; Wang, M. ; Bi, W. ; Li, H. ; Chen, D. Da Yong High-Throughput Analysis For Artemisinins With Deep Eutectic Solvents Mechanochemical Extraction And Direct Analysis In Real Time Mass Spectrometry. Analytical Chemistry 2018, 90 (5), pp , 3109–3117.
Ma, H. ; Jiang, Q. ; Dai, D. ; Li, H. ; Bi, W. ; Chen, D. Da Yong Direct Analysis In Real Time Mass Spectrometry For Characterization Of Large Saccharides. Analytical Chemistry 2018, 90, 3628-3636.
Ma, H. ; Zhang, K. ; Jiang, Q. ; Dai, D. ; Li, H. ; Bi, W. ; Chen, D. Da Yong Characterization Of Plant Polysaccharides From Dendrobium Officinale By Multiple Chromatographic And Mass Spectrometric Techniques. Journal of Chromatography A 2018, 1547, 29 - 36.
Yang, S. - S. ; Chang, Y. - J. ; Zhang, H. ; Yu, X. ; Shang, W. ; Chen, G. - Q. ; Chen, D. D. Y. ; Gu, Z. - Y. Enrichment Of Phosphorylated Peptides With Metal–Organic Framework Nanosheets For Serum Profiling Of Diabetes And Phosphoproteomics Analysis. Analytical Chemistry 2018, 90, 13796-13805.
MacLennan, M. S. ; Peru, K. M. ; Swyngedouw, C. ; Fleming, I. ; Chen, D. D. Y. ; Headley, J. V. Characterization Of Athabasca Lean Oil Sands And Mixed Surficial Materials: Comparison Of Capillary Electrophoresis-Low Resolution Mass Spectrometry And High-Resolution Mass Spectrometry. Rapid Communications in Mass Spectrometry 2018, 32, 695-702.
Zhang, K. ; Ma, H. ; Yan, P. ; Tong, W. ; Huang, X. ; Chen, D. D. Y. Electrochemical Detection Of Microcystin-Lr Based On Its Deleterious Effect On Dna. Talanta 2018, 185, 405-410.
Kovalchik, K. A. ; Moggridge, S. ; Chen, D. D. Y. ; Morin, G. B. ; Hughes, C. S. Parsing And Quantification Of Raw Orbitrap Mass Spectrometer Data Using Rawquant. Journal of Proteome Research 2018, 17, 2237-2247.
Cheng, Q. ; Su, W. ; Hengqing, F. ; B., T. Robin F. ; Huihui, L. ; Y., C. David D. Pressure-Assisted Capillary Electrophoresis Frontal Analysis For Faster Binding Constant Determination. ELECTROPHORESIS 2018, 39, 1786-1793.
Wang, L. ; Bo, T. ; Zhang, Z. ; Wang, G. ; Tong, W. ; Chen, D. D. Y. High Resolution Capillary Isoelectric Focusing Mass Spectrometry Analysis Of Peptides, Proteins, And Monoclonal Antibodies With A Flow-Through Microvial Interface. Analytical Chemistry 2018, 90, 9495-9503.
Wang, L. ; Tong, W. ; Chen, D. D. Y. Optimization Of Dynamic Ph Barrage Junction Focusing For Weakly Alkaline Or Zwitterionic Analytes In Capillary Electrophoresis. Journal of Chromatography B 2018, 1095, 94 - 102.

2017

Khodabandehloo, A. ; Chen, D. Da Yong Particle Sizing Methods For The Detection Of Protein Aggregates In Biopharmaceuticals. Bioanalysis 2017, 9, 313 - 326.
Wang, L. ; He, J. ; Yang, Q. ; Li, X. ; Wei, H. ; Chen, D. D. Y. ; Huang, X. A Preliminary Study On The Effects Of Lanthanum (Iii) On Plant Vitronectin-Like Protein And Its Toxicological Basis. Ecotoxicol Environ Saf 2017, 145, 227-234.
Cheng, J. ; Wang, L. ; Liu, W. ; Chen, D. D. Y. Quantitative Nonaqueous Capillary Electrophoresis–Mass Spectrometry Method For Determining Active Ingredients In Plant Extracts. Analytical Chemistry 2017, 89, 1411-1415.
Li, D. ; Zhu, J. ; Wang, M. ; Bi, W. ; Huang, X. ; Chen, D. Da Yong Extraction Of Trace Polychlorinated Biphenyls In Environmental Waters By Well-Dispersed Velvet-Like Magnetic Carbon Nitride Nanocomposites. Journal of Chromatography A 2017, 1491, 27 - 35.
Wang, J. ; Zhu, J. ; Si, L. ; Du, Q. ; Li, H. ; Bi, W. ; Chen, D. Da Yong High Throughput Screening Of Phenoxy Carboxylic Acids With Dispersive Solid Phase Extraction Followed By Direct Analysis In Real Time Mass Spectrometry. Analytica Chimica Acta 2017, 996, 20 - 28.
Fan, S. ; Zhu, J. ; Ren, L. ; Wang, M. ; Bi, W. ; Li, H. ; Huang, X. ; Chen, D. Da Yong Co-Solvent Enhanced Adsorption With Magnetic Velvet-Like Carbon Nitride For High Efficiency Solid Phase Extraction. Analytica Chimica Acta 2017, 960, 63 - 71.
Wang, L. ; Yu, L. ; Grist, S. ; Cheung, K. C. ; Chen, D. D. Y. Different In Vitro Cellular Responses To Tamoxifen Treatment In Polydimethylsiloxane-Based Devices Compared To Normal Cell Culture. Journal of Chromatography B 2017, 1068-1069, 105 - 111.
Qian, C. ; Kovalchik, K. A. ; MacLennan, M. S. ; Huang, X. ; Chen, D. D. Y. Mobility-Based Correction For Accurate Determination Of Binding Constants By Capillary Electrophoresis-Frontal Analysis. ELECTROPHORESIS 2017, 38, 1572-1581.
Risley, J. May; Chen, D. Da Yong Improved Sensitivity By Post-Column Chemical Environment Modification Of Ce-Esi-Ms Using A Flow-Through Microvial Interface. ELECTROPHORESIS 2017, 38, 1644–1648.
Wang, M. ; Wang, J. ; Zhou, Y. ; Zhang, M. ; Xia, Q. ; Bi, W. ; Chen, D. Da Yong Ecofriendly Mechanochemical Extraction Of Bioactive Compounds From Plants With Deep Eutectic Solvents. ACS Sustainable Chemistry & Engineering 2017, 5, 6297−6303.
Kovalchik, K. A. ; MacLennan, M. S. ; Peru, K. M. ; Headley, J. V. ; Chen, D. D. Y. Standard Method Design Considerations For Semi-Quantification Of Total Naphthenic Acids In Oil Sands Process Affected Water By Mass Spectrometry: A Review. Frontiers of Chemical Science and Engineering 2017, 11, 497-507.
Khodabandehloo, A. ; Chen, D. D. Y. Electroosmotic Flow Dispersion Of Large Molecules In Electrokinetic Migration. Analytical Chemistry 2017, 89, 7823-7827.
Wang, L. ; He, J. ; Yang, Q. ; Lv, X. ; Li, J. ; Chen, D. D. Y. ; Ding, X. ; Huang, X. ; Zhou, Q. Abnormal Pinocytosis And Valence-Variable Behaviors Of Cerium Suggested A Cellular Mechanism For Plant Yield Reduction Induced By Environmental Cerium. Environmental Pollution 2017, 230, 902 - 910.
Qian, C. ; Fu, H. ; Kovalchik, K. A. ; Li, H. ; Chen, D. Da Yong Specific Binding Constant And Stoichiometry Determination In Free Solution By Mass Spectrometry And Capillary Electrophoresis Frontal Analysis. Analytical Chemistry 2017, 89, 9483-9490.
Zhou, J. ; Huang, Z. - A. ; Kumar, U. ; Chen, D. D. Y. Review Of Recent Developments In Determining Volatile Organic Compounds In Exhaled Breath As Biomarkers For Lung Cancer Diagnosis. Analytica Chimica Acta 2017, 996, 1-9.
Kovalchik, K. A. ; MacLennan, M. S. ; Peru, K. M. ; Ajaero, C. ; McMartin, D. W. ; Headley, J. V. ; Chen, D. D. Y. Characterization Of Dicarboxylic Naphthenic Acid Fraction Compounds Utilizing Amide Derivatization: Proof Of Concept. Rapid Communications in Mass Spectrometry 2017, 31, 2057-2065.

2016

MacLennan, M. S. ; Tie, C. ; Kovalchik, K. ; Peru, K. M. ; Zhang, X. ; Headley, J. V. ; Chen, D. D. Y. Potential Of Capillary Electrophoresis Mass Spectrometry For The Characterization And Monitoring Of Amine-Derivatized Naphthenic Acids From Oil Sands Process-Affected Water. JOURNAL OF ENVIRONMENTAL SCIENCES 2016, 49, 203-212.
De Jong, C. A. ; Risley, J. ; Lee, A. K. ; Zhao, S. S. ; Chen, D. D. Y. Separation Of Recombinant Therapeutic Proteins Using Capillary Gel Electrophoresis And Capillary Isoelectric Focusing. In Capillary Electrophoresis of Proteins and Peptides; Capillary Electrophoresis of Proteins and Peptides; Springer Nature: New York, 2016; pp. 137-149.
Risley, J. ; De Jong, C. A. G. ; Chen, D. D. Y. Electrospray Ionization Interface Development For Capillary Electrophoresis–Mass Spectrometry. In Capillary Electrophoresis–Mass Spectrometry (CE-MS); Capillary Electrophoresis–Mass Spectrometry (CE-MS); Wiley-VCH Verlag GmbH & Co. KGaA, 2016; pp. 7–39.
Wang, L. ; Cheng, M. ; Chu, Y. ; Li, X. ; Chen, D. D. Y. ; Huang, X. ; Zhou, Q. Responses Of Plant Calmodulin To Endocytosis Induced By Rare Earth Elements. CHEMOSPHERE 2016, 154, 408-415.
Wang, M. ; Bi, W. ; Huang, X. ; Chen, D. Da Yong Ball Mill Assisted Rapid Mechanochemical Extraction Method For Natural Products From Plants. JOURNAL OF CHROMATOGRAPHY A 2016, 1449, 8-16.
Wang, L. ; MacDonald, D. ; Huang, X. ; Chen, D. D. Y. Capture Efficiency Of Dynamic Ph Junction Focusing In Capillary Electrophoresis. ELECTROPHORESIS 2016, 37, 1143-1150.
Wang, M. ; Wang, J. ; Zhang, Y. ; Xia, Q. ; Bi, W. ; Yang, X. ; Chen, D. Da Yong Fast Environment-Friendly Ball Mill-Assisted Deep Eutectic Solvent-Based Extraction Of Natural Products. JOURNAL OF CHROMATOGRAPHY A 2016, 1443, 262-266.
Ansley, D. M. ; Raedschelders, K. ; Choi, P. T. ; Wang, B. ; Cook, R. C. ; Chen, D. D. Y. Propofol Cardioprotection For On-Pump Aortocoronary Bypass Surgery In Patients With Type 2 Diabetes Mellitus (Pro-Tect Ii): A Phase 2 Randomized-Controlled Trial. CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE 2016, 63, 442-453.

2014

Liu, C. ; Chen, D. D. Y. Comparison Of Sample Introduction Methods For Continuous Chemical Purification In Two-Dimensional Electro-Fluid-Dynamic Devices. ANALYTICAL CHEMISTRY 2014, 86, 11380-11386.
Jayo, R. G. ; Thaysen-Andersen, M. ; Lindenburg, P. W. ; Haselberg, R. ; Hankemeier, T. ; Ramautar, R. ; Chen, D. D. Y. Simple Capillary Electrophoresis-Mass Spectrometry Method For Complex Glycan Analysis Using A Flow-Through Microvial Interface. ANALYTICAL CHEMISTRY 2014, 86, 6479-6486.
Lindenburg, P. W. ; Ramautar, R. ; Jayo, R. G. ; Chen, D. D. Y. ; Hankemeier, T. Capillary Electrophoresis-Mass Spectrometry Using A Flow-Through Microvial Interface For Cationic Metabolome Analysis. ELECTROPHORESIS 2014, 35, 1308-1314.
Zhao, S. Sherry; Chen, D. D. Y. Applications Of Capillary Electrophoresis In Characterizing Recombinant Protein Therapeutics. ELECTROPHORESIS 2014, 35, 96-108.

2013

Liu, C. ; Chen, D. D. Y. ; Yu, L. ; Luo, Y. Live Cell Refractometry Based On Non-Spr Microparticle Sensor. ELECTROPHORESIS 2013, 34, 1526-1529.

2012

Soliman, L. C. ; Hui, Y. ; Hewavitharana, A. K. ; Chen, D. D. Y. Monitoring Potential Prostate Cancer Biomarkers In Urine By Capillary Electrophoresis-Tandem Mass Spectrometry. JOURNAL OF CHROMATOGRAPHY A 2012, 1267, 162-169.
Sumer-Bayraktar, Z. ; Nguyen-Khuong, T. ; Jayo, R. ; Chen, D. D. Y. ; Ali, S. ; Packer, N. H. ; Thaysen-Andersen, M. Micro- And Macroheterogeneity Of N-Glycosylation Yields Size And Charge Isoforms Of Human Sex Hormone Binding Globulin Circulating In Serum. PROTEOMICS 2012, 12, 3315-3327.
Jayo, R. G. ; Li, J. ; Chen, D. D. Y. Capillary Electrophoresis Mass Spectrometry For The Characterization Of O-Acetylated N-Glycans From Fish Serum. ANALYTICAL CHEMISTRY 2012, 84, 8756-8762.
Zhao, S. Sherry; Zhong, X. ; Tie, C. ; Chen, D. D. Y. Capillary Electrophoresis-Mass Spectrometry For Analysis Of Complex Samples. PROTEOMICS 2012, 12, 2991-3012.
Hui, Y. ; Wong, M. ; Kim, J. - O. ; Love, J. ; Ansley, D. M. ; Chen, D. D. Y. A New Derivatization Method Coupled With Lc-Ms/ms To Enable Baseline Separation And Quantification Of Dimethylarginines In Human Plasma From Patients To Receive On-Pump Cabg Surgery. ELECTROPHORESIS 2012, 33, 1911-1920.
Zhao, S. Sherry; Zhong, X. ; Chen, D. D. Y. Atmospheric Pressure Ion Lens Extends The Stable Operational Region Of An Electrospray Ion Source For Capillary Electrophoresis-Mass Spectrometry. ELECTROPHORESIS 2012, 33, 1322-1330.
Hui, Y. ; Zhao, S. Sherry; Love, J. A. ; Ansley, D. M. ; Chen, D. D. Y. Development And Application Of A Lc-Ms/ms Method To Quantify Basal Adenosine Concentration In Human Plasma From Patients Undergoing On-Pump Cabg Surgery. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 2012, 885, 30-36.
Hui, Y. ; Wong, M. ; Zhao, S. Sherry; Love, J. A. ; Ansley, D. M. ; Chen, D. D. Y. A Simple And Robust Lc-Ms/ms Method For Quantification Of Free 3-Nitrotyrosine In Human Plasma From Patients Receiving On-Pump Cabg Surgery. ELECTROPHORESIS 2012, 33, 697-704.
Raedschelders, K. ; Ansley, D. M. ; Chen, D. D. Y. The Cellular And Molecular Origin Of Reactive Oxygen Species Generation During Myocardial Ischemia And Reperfusion. PHARMACOLOGY & THERAPEUTICS 2012, 133, 230-255.
Ma, M. ; Kazemzadeh-Narbat, M. ; Hui, Y. ; Lu, S. ; Ding, C. ; Chen, D. D. Y. ; Hancock, R. E. W. ; Wang, R. Local Delivery Of Antimicrobial Peptides Using Self-Organized Tio2 Nanotube Arrays For Peri-Implant Infections. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 2012, 100A, 278-285.

2011

Zhong, X. ; E. Maxwell, J. ; Chen, D. D. Y. Mass Transport In A Micro Flow-Through Vial Of A Junction-At-The-Tip Capillary Electrophoresis-Mass Spectrometry Interface. ANALYTICAL CHEMISTRY 2011, 83, 4916-4923.
Wang, B. ; Raedschelders, K. ; Shravah, J. ; Hui, Y. ; Safaei, H. G. ; Chen, D. D. Y. ; Cook, R. C. ; Fradet, G. ; Au, C. L. ; Ansley, D. M. Differences In Myocardial Pten Expression And Akt Signalling In Type 2 Diabetic And Nondiabetic Patients Undergoing Coronary Bypass Surgery. CLINICAL ENDOCRINOLOGY 2011, 74, 705-713.
Liu, C. ; Luo, Y. ; Fang, N. ; Chen, D. D. Y. Analyte Distribution At Channel Intersections Of Electro-Fluid-Dynamic Devices. ANALYTICAL CHEMISTRY 2011, 83, 1189-1192.
Zhong, X. ; E. Maxwell, J. ; Ratnayake, C. ; Mack, S. ; Chen, D. D. Y. Flow-Through Microvial Facilitating Interface Of Capillary Isoelectric Focusing And Electrospray Ionization Mass Spectrometry. ANALYTICAL CHEMISTRY 2011, 83, 8748-8755.
Liu, C. ; Luo, Y. ; E. Maxwell, J. ; Fang, N. ; Chen, D. D. Y. Potential Of Two-Dimensional Electro-Fluid-Dynamic Devices For Continuous Purification Of Multiple Components From Complex Samples. ANALYTICAL CHEMISTRY 2011, 83, 8208-8214.
E. Maxwell, J. ; Ratnayake, C. ; Jayo, R. ; Zhong, X. ; Chen, D. D. Y. A Promising Capillary Electrophoresis-Electrospray Ionization-Mass Spectrometry Method For Carbohydrate Analysis. ELECTROPHORESIS 2011, 32, 2161-2166.

2010

E. Maxwell, J. ; Zhong, X. ; Chen, D. D. Y. Asymmetrical Emitter Geometries For Increased Range Of Stable Electrospray Flow Rates. ANALYTICAL CHEMISTRY 2010, 82, 8377-8381.
Jayo, R. G. ; Chen, D. D. Y. Capillary Electrophoresis Analysis Of Peptides And Proteins Using A Polyethyleneimine-Coated Capillary With Uv And Ms Detection. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 2010, 240.
Liu, C. ; Luo, Y. ; Maxwell, E. J. ; Fang, N. ; Chen, D. D. Y. Reverse Of Mixing Process With A Two-Dimensional Electro-Fluid-Dynamic Device. Analytical Chemistry 2010, 82, 2182 - 2185.
Liu, C. ; Park, H. M. ; Monsalve, M. V. ; Chen, D. D. Y. Free Fatty Acids Composition In Adipocere Of The Kwaday Dan Ts'inchi Ancient Remains Found In A Glacier. JOURNAL OF FORENSIC SCIENCES 2010, 55, 1039-1043.
E. Maxwell, J. ; Zhong, X. ; Zhang, H. ; van Zeijl, N. ; Chen, D. D. Y. Decoupling Ce And Esi For A More Robust Interface With Ms. ELECTROPHORESIS 2010, 31, 1130-1137.

2009

Raedschelders, K. ; Hui, Y. ; Laferlita, B. ; Luo, T. ; Zhang, H. ; Chen, D. D. Y. ; Ansley, D. M. Target-Achieved Propofol Concentration During On-Pump Cardiac Surgery: A Pilot Dose-Finding Study. Canadian Journal of Anaesthesia-Journal Canadien D Anesthesie 2009, 56, 658-666.
Wang, B. H. ; Shravah, J. ; Luo, H. L. ; Raedschelders, K. ; Chen, D. D. Y. ; Ansley, D. M. Propofol Protects Against Hydrogen Peroxide-Induced Injury In Cardiac H9C2 Cells Via Akt Activation And Bcl-2 Up-Regulation. Biochemical and Biophysical Research Communications 2009, 389, 105-111.
Cressman, S. ; Sun, Y. ; Maxwell, E. J. ; Fang, N. ; Chen, D. D. Y. ; Cullis, P. R. Binding And Uptake Of Rgd-Containing Ligands To Cellular Alpha(V)Beta(3) Integrins. International Journal of Peptide Research and Therapeutics 2009, 15, 49-59.
Zhong, X. F. ; Yi, R. ; Holliday, A. E. ; Chen, D. D. Y. Field Distribution In An Electrospray Ionization Source Determined By Finite Element Method. Rapid Communications in Mass Spectrometry 2009, 23, 689-697.
Hui, Y. ; Raedschelders, K. ; Zhang, H. ; Ansley, D. M. ; Chen, D. D. Y. Quantitative Analysis Of Propofol In Whole Blood Using Capillary Electrophoresis. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 2009, 877, 703-709.
Ansley, D. M. ; Raedschelders, K. ; Chen, D. D. Y. ; Choi, P. T. Rationale, Design And Baseline Characteristics Of The Project Ii Study: Propofol Cardioprotection For Type Ii Diabetics A Randomized, Controlled Trial Of High-Dose Propofol Versus Isoflurane Preconditioning In Patients Undergoing On-Pump Coronary Artery B. Contemporary Clinical Trials 2009, 30, 380-385.

2008

Maxwell, E. J. ; Chen, D. D. Y. Twenty Years Of Interface Development For Capillary Electrophoresis-Electrospray Ionization-Mass Spectrometry. Analytica Chimica Acta 2008, 627, 25-33.
Sun, Y. ; Cressman, S. ; Fang, N. ; Cullis, P. R. ; Chen, D. D. Y. Capillary Electrophoresis Frontal Analysis For Characterization Of Alpha(V)Beta(3) Integrin Binding Interactions. Analytical Chemistry 2008, 80, 3105-3111.
Sun, Y. ; Fang, N. ; Chen, D. D. Y. ; Donkor, K. K. Determination Of Potentially Anti-Carcinogenic Flavonoids In Wines By Micellar Electrokinetic Chromatography. Food Chemistry 2008, 106, 415-420.
Sun, Y. ; Fang, N. ; Chen, D. D. Y. Behavior Of Interacting Species In Vacancy Affinity Capillary Electrophoresis Described By Mass Balance Equation. Electrophoresis 2008, 29, 3333-3341.

2007

Fang, N. ; Sun, Y. ; Zheng, J. Y. ; Chen, D. D. Y. Computer Simulation Of Different Modes Of Ace Based On The Dynamic Complexation Model. Electrophoresis 2007, 28, 3214-3222.
Fang, N. ; Meng, P. J. ; Zhang, H. ; Ying, S. ; Chen, D. D. Y. Systematic Optimization Of Exhaustive Electrokinetic Injection Combined With Micellar Sweeping In Capillary Electrophoresis. Analyst 2007, 132, 127-134.
Cressman, S. ; Sun, S. ; Dobson, I. T. ; Chen, D. D. Y. ; Cullis, P. R. C. A Two-Site Binding Stoichiometry To Describe Rgd Binding To The Alpha V Beta 3 Integrin. Biopolymers 2007, 88, 634-634.

2006

Fang, N. ; Chen, D. D. Y. Behavior Of Interacting Species In Capillary Electrophoresis Described By Mass Transfer Equation. Analytical Chemistry 2006, 78, 1832-1840.
Manisali, I. ; Chen, D. D. Y. ; Schneider, B. B. Electrospray Ionization Source Geometry For Mass Spectrometry: Past, Present, And Future. Trac-Trends in Analytical Chemistry 2006, 25, 243-256.
Meng, P. J. ; Fang, N. ; Wang, M. ; Liu, H. W. ; Chen, D. D. Y. Analysis Of Amphetamine, Methamphetamine And Methylenedioxy-Methamphetamine By Micellar Capillary Electrophoresis Using Cation-Selective Exhaustive Injection. Electrophoresis 2006, 27, 3210-3217.

2005

Fang, N. ; Chen, D. D. Y. General Approach To High-Efficiency Simulation Of Affinity Capillary Electrophoresis. Analytical Chemistry 2005, 77, 840-847.
Fang, N. ; Chen, D. D. Y. Enumeration Algorithm For Determination Of Binding Constants In Capillary Electrophoresis. Analytical Chemistry 2005, 77, 2415-2420.

2004

Fang, N. ; Ting, E. ; Chen, D. D. Y. Determination Of Shapes And Maximums Of Analyte Peaks Based On Solute Mobilitiess In Capillary Electrophoresis. Analytical Chemistry 2004, 76, 1708-1714.
McLaren, D. G. ; Chen, D. D. Y. Continuous Electrophoretic Purification Of Individual Analytes From Multicomponent Mixtures. Analytical Chemistry 2004, 76, 2298-2305.

2003

Britz-McKibbin, P. ; Ichihashi, T. ; Tsubota, K. ; Chen, D. D. Y. ; Terabe, S. Complementary On-Line Preconcentration Strategies For Steroids By Capillary Electrophoresis. Journal of Chromatography A 2003, 1013, 65-76.
McLaren, D. G. ; Chen, D. D. Y. A Quantitative Study Of Continuous Flow-Counterbalanced Capillary Electrophoresis For Sample Purification. Electrophoresis 2003, 24, 2887-2895.
Grob, M. K. ; O’Brien, K. ; Chu, J. J. ; Chen, D. D. Y. Optimization Of Cellular Nucleotide Extraction And Sample Preparation For Nucleotide Pool Analyses Using Capillary Electrophoresis. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 2003, 788, 103-111.
Britz-McKibbin, P. ; Chen, D. D. Y. Velocity-Difference Induced Focusing Of Xanthine And Purine Metabolites By Capillary Electrophoresis Using A Dynamic Ph Junction. Chromatographia 2003, 57, 87-93.
Galbusera, C. ; Chen, D. D. Y. Molecular Interaction In Capillary Electrophoresis. Current Opinion in Biotechnology 2003, 14, 126-130.

2002

Heegaard, N. H. H. ; Nissen, M. H. ; Chen, D. D. Y. Applications Of On-Line Weak Affinity Interactions In Free Solution Capillary Electrophoresis. Electrophoresis 2002, 23, 815-822.
McLaren, D. G. ; Boulat, O. ; Chen, D. D. Y. Univalent Salts As Modifiers In Micellar Capillary Electrophoresis. Electrophoresis 2002, 23, 1912-1920.
Duso, A. B. ; Chen, D. D. Y. Proton And Hydroxide Ion Mobility In Capillary Electrophoresis. Analytical Chemistry 2002, 74, 2938-2942.
Schneider, B. B. ; Douglas, D. J. ; Chen, D. D. Y. An Atmospheric Pressure Ion Lens That Improves Nebulizer Assisted Electrospray Ion Sources. Journal of the American Society for Mass Spectrometry 2002, 13, 906-913.
Galbusera, C. ; Thachuk, M. ; De Lorenzi, E. ; Chen, D. D. Y. Affinity Capillary Electrophoresis Using A Low-Concentration Additive With The Consideration Of Relative Mobilities. Analytical Chemistry 2002, 74, 1903-1914.
Schneider, B. B. ; Douglas, D. J. ; Chen, D. D. Y. Multiple Sprayer System For High-Throughput Electrospray Ionization Mass Spectrometry. Rapid Communications in Mass Spectrometry 2002, 16, 1982-1990.
Britz-McKibbin, P. ; Chen, D. D. Y. Accurately Describing Weak Analyte-Additive Interactions By Capillary Electrophoresis. Electrophoresis 2002, 23, 880-888.

2001

Schneider, B. B. ; Douglas, D. J. ; Chen, D. D. Y. Collision-Induced Dissociation Of Bradykinin Ions In The Interface Region Of An Esi-Ms. Journal of the American Society for Mass Spectrometry 2001, 12, 772-779.
Boulat, O. ; McLaren, D. G. ; Arriaga, E. A. ; Chen, D. D. Y. Separation Of Free Amino Acids In Human Plasma By Capillary Electrophoresis With Laser Induced Fluorescence: Potential For Emergency Diagnosis Of Inborn Errors Of Metabolism. Journal of Chromatography B 2001, 754, 217-228.
Schneider, B. B. ; Douglas, D. J. ; Chen, D. D. Y. An Atmospheric Pressure Ion Lens To Improve Electrospray Ionization At Low Solution Flow-Rates. Rapid Communications in Mass Spectrometry 2001, 15, 2168-2175.

2000

Britz-McKibbin, P. ; Chen, D. D. Y. Selective Focusing Of Catecholamines And Weakly Acidic Compounds By Capillary Electrophoresis Using A Dynamic Ph Junction. Analytical Chemistry 2000, 72, 1242-1252.
Schneider, B. B. ; Chen, D. D. Y. Collision-Induced Dissociation Of Ions Within The Orifice-Skimmer Region Of An Electrospray Mass Spectrometer. Analytical Chemistry 2000, 72, 791-799.
Britz-McKibbin, P. ; Bebault, G. M. ; Chen, D. D. Y. Velocity-Difference Induced Focusing Of Nucleotides In Capillary Electrophoresis With A Dynamic Ph Junction. Analytical Chemistry 2000, 72, 1729-1735.

1999

Bowser, M. T. ; Chen, D. D. Y. Monte Carlo Simulation Of Error Propagation In The Determination Of Binding Constants From Rectangular Hyperbolae. 2. Effect Of The Maximum-Response Range. Journal of Physical Chemistry A 1999, 103, 197-202.
Vo, H. C. ; Britz-McKibbin, P. ; Chen, D. D. Y. ; MacGillivray, R. T. A. Undercarboxylation Of Recombinant Prothrombin Revealed By Analysis Of Gamma-Carboxyglutamic Acid Using Capillary Electrophoresis And Laser-Induced Fluorescence. Febs Letters 1999, 445, 256-260.
Britz-McKibbin, P. ; Wong, J. ; Chen, D. D. Y. Analysis Of Epinephrine From Fifteen Different Dental Anesthetic Formulations By Capillary Electrophoresis. Journal of Chromatography A 1999, 853, 535-540.
Britz-McKibbin, P. ; Vo, H. C. ; MacGillivray, R. T. A. ; Chen, D. D. Y. Analysis Of Gamma-Carboxyglutamic Acid Content Of Protein, Urine, And Plasma By Capillary Electrophoresis And Laser-Induced Fluorescence. Analytical Chemistry 1999, 71, 1633-1637.

1998

Bowser, M. T. ; Chen, D. D. Y. Monte Carlo Simulation Of Error Propagation In The Determination Of Binding Constants From Rectangular Hyperbolae. 1. Ligand Concentration Range And Binding Constant. Journal of Physical Chemistry A 1998, 102, 8063-8071.
Bowser, M. T. ; Chen, D. D. Y. Dynamic Complexation Of Solutes In Capillary Electrophoresis. Electrophoresis 1998, 19, 383-387.
Kranack, A. R. ; Bowser, M. T. ; Britz-McKibbin, P. ; Chen, D. D. Y. The Effects Of A Mixture Of Charged And Neutral Additives On Analyte Migration Behavior In Capillary Electrophoresis. Electrophoresis 1998, 19, 388-396.
Bowser, M. T. ; Kranack, A. R. ; Chen, D. D. Y. Properties Of Multivariate Binding Isotherms In Capillary Electrophoresis. Analytical Chemistry 1998, 70, 1076-1084.
Britr-McKibbin, P. ; Chen, D. D. Y. A Water-Soluble Tetraethylsulfonate Derivative Of 2-Methylresorcinarene As An Additive For Capillary Electrophoresis. Analytical Chemistry 1998, 70, 907-912.
Bowser, M. T. ; Chen, D. D. Y. The Effect Of Complexation Additives On Analyte Migration Behavior In Capillary Electrochromatography. Electrophoresis 1998, 19, 1452-1460.
Britz-McKibbin, P. ; Kranack, A. R. ; Paprica, A. ; Chen, D. D. Y. Quantitative Assay Fdr Epinephrine In Dental Anesthetic Solutions By Capillary Electrophoresis. Analyst 1998, 123, 1461-1463.
Bowser, M. T. ; Chen, D. D. Y. Recent Developments Towards A Unified Theory For Separation Science. Electrophoresis 1998, 19, 1586-1589.
Lucy, C. A. ; Yeung, K. K. C. ; Pang, X. J. ; Chen, D. D. Y. Extraseparation Peak Broadening In Capillary Electrophoresis. Lc Gc-Magazine of Separation Science 1998, 16, 26-+.
Bowser, M. T. ; Kranack, A. R. ; Chen, D. D. Y. Analyte-Additive Interactions In Nonaqueous Capillary Electrophoresis: A Critical Review. Trac-Trends in Analytical Chemistry 1998, 17, 424-434.
Bowser, M. T. ; Chen, D. D. Y. Higher Order Equilibria And Their Effect On Analyte Migration Behavior In Capillary Electrophoresis. Analytical Chemistry 1998, 70, 3261-3270.

1997

Peng, X. J. ; Chen, D. D. Y. Variance Contributed By Pressure Induced Injection In Capillary Electrophoresis. Journal of Chromatography A 1997, 767, 205-216.
BritzMcKibbin, P. ; Chen, D. D. Y. Prediction Of The Migration Behavior Of Analytes In Capillary Electrophoresis Based On Three Fundamental Parameters. Journal of Chromatography A 1997, 781, 23-34.
Peng, X. J. ; Bowser, M. T. ; BritzMcKibbin, P. ; Bebault, G. M. ; Morris, J. R. ; Chen, D. D. Y. Quantitative Description Of Analyte Migration Behavior Based On Dynamic Complexation In Capillary Electrophoresis With One Or More Additives. Electrophoresis 1997, 18, 706-716.
Peng, X. J. ; Bebault, G. M. ; Sacks, S. L. ; Chen, D. D. Y. Quantitative Description Of Analyte Migration Behavior Based On The Dynamic Complexation Model In Capillary Electrophoresis. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1997, 75, 507-517.
Bowser, M. T. ; Sternberg, E. D. ; Chen, D. D. Y. Quantitative Description Of Migration Behavior Of Porphyrins Based On The Dynamic Complexation Model In A Nonaqueous Capillary Electrophoresis System. Electrophoresis 1997, 18, 82-91.
Bowser, M. T. ; Bebault, G. M. ; Peng, X. J. ; Chen, D. D. Y. Redefining The Separation Factor: A Potential Pathway To A Unified Separation Science. Electrophoresis 1997, 18, 2928-2934.

1996

Bowser, M. T. ; Sternberg, E. D. ; Chen, D. D. Y. Development And Application Of A Nonaqueous Capillary Electrophoresis System For The Analysis Of Porphyrins And Their Oligomers (Photofrin). Analytical Biochemistry 1996, 241, 143-150.